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1
Transmembrane signaling of interleukin 2 receptor. Conformation and function of human interleukin 2 receptor (p55)/insulin receptor chimeric molecules.白细胞介素2受体的跨膜信号传导。人白细胞介素2受体（p55）/胰岛素受体嵌合分子的构象与功能。
J Exp Med. 1987 Aug 1;166(2):362-75. doi: 10.1084/jem.166.2.362.
2
Intracytoplasmic phosphorylation sites of Tac antigen (p55) are not essential for the conformation, function, and regulation of the human interleukin 2 receptor.Tac抗原（p55）的胞浆内磷酸化位点对于人白细胞介素2受体的构象、功能及调节并非必不可少。
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9650-4. doi: 10.1073/pnas.83.24.9650.
3
Structure of the functional interleukin-2 receptor. Evidence for the association of human p55 and murine p75 molecules in a mouse T cell line.功能性白细胞介素-2受体的结构。小鼠T细胞系中人类p55和小鼠p75分子关联的证据。
Int Immunol. 1989;1(2):160-8. doi: 10.1093/intimm/1.2.160.
4
The CD3 zeta cytoplasmic domain mediates CD2-induced T cell activation.CD3 ζ 细胞质结构域介导 CD2 诱导的 T 细胞活化。
J Exp Med. 1992 Jul 1;176(1):139-45. doi: 10.1084/jem.176.1.139.
5
Interleukin 7 receptor functions by recruiting the tyrosine kinase p59fyn through a segment of its cytoplasmic tail.白细胞介素7受体通过其细胞质尾部的一段区域募集酪氨酸激酶p59fyn发挥作用。
Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12083-7. doi: 10.1073/pnas.89.24.12083.
6
Cytosolic domain of the type I interleukin-1 receptor spontaneously recruits signaling molecules to activate a proinflammatory gene.I型白细胞介素-1受体的胞质结构域可自发募集信号分子以激活促炎基因。
J Clin Invest. 1997 Jul 15;100(2):419-28. doi: 10.1172/JCI119549.
7
Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain.人B细胞前体急性淋巴细胞白血病细胞和小鼠BAF3细胞中的白细胞介素-7信号传导涉及经由白细胞介素-7受体α链介导的STAT1和STAT5的激活。
Leukemia. 1996 Aug;10(8):1317-25.
8
Lymphocyte activation and capping of hormone receptors.
J Cell Biochem. 1988 Jun;37(2):131-50. doi: 10.1002/jcb.240370202.
9
Transmembrane signaling by an insulin receptor lacking a cytoplasmic beta-subunit domain.缺乏细胞质β亚基结构域的胰岛素受体介导的跨膜信号传导。
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4379-83. doi: 10.1073/pnas.90.10.4379.
10
The monocyte interleukin-2 receptor light chain: production of cell-associated and soluble interleukin-2 receptor by monocytes.单核细胞白细胞介素-2受体轻链：单核细胞产生细胞相关和可溶性白细胞介素-2受体。
Immunology. 1992 Feb;75(2):299-304.

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1
Evolution and synthetic biology.进化与合成生物学。
Curr Opin Microbiol. 2023 Dec;76:102394. doi: 10.1016/j.mib.2023.102394. Epub 2023 Oct 4.
2
Differential effects of tumour necrosis factor-alpha and interleukin-12 on isopentenyl pyrophosphate-stimulated interferon-gamma production by cord blood Vgamma9 T cells.肿瘤坏死因子-α和白细胞介素-12对异戊烯基焦磷酸刺激的脐血Vγ9 T细胞产生干扰素-γ的不同作用。
Immunology. 2009 Jun;127(2):171-7. doi: 10.1111/j.1365-2567.2008.02983.x. Epub 2008 Nov 14.
3
Intermediate- and high-affinity interleukin-2 receptors expressed in an IL-4-dependent T-cell line induce different signals.在白细胞介素-4依赖的T细胞系中表达的中亲和性及高亲和性白细胞介素-2受体可诱导不同信号。
Immunology. 1993 Oct;80(2):229-35.
4
Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes.B淋巴细胞CD21/CD19/TAPA-1/Leu-13复合物的功能剖析
J Exp Med. 1993 Oct 1;178(4):1407-17. doi: 10.1084/jem.178.4.1407.
5
Dysregulation of growth factor-receptor system in cellular transformation.细胞转化过程中生长因子-受体系统的失调。
Jpn J Cancer Res. 1988 Aug;79(8):885-901. doi: 10.1111/j.1349-7006.1988.tb00052.x.
6
Binding specificity and intramolecular signal transmission of uncleaved insulin proreceptor in transformed lymphocytes from a patient with extreme insulin resistance.一名极度胰岛素抵抗患者转化淋巴细胞中未裂解胰岛素原受体的结合特异性和分子内信号转导
Diabetologia. 1989 Jun;32(6):371-7. doi: 10.1007/BF00277261.
7
Murine interleukin 2 receptor beta chain: dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion.小鼠白细胞介素2受体β链：由启动子插入导致淋巴瘤细胞系EL-4中基因表达失调
Proc Natl Acad Sci U S A. 1990 Mar;87(5):1806-10. doi: 10.1073/pnas.87.5.1806.
8
Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.人GM-CSF、IL-3和IL-5受体共同β亚基用于生长信号转导和酪氨酸磷酸化的关键胞质结构域。
EMBO J. 1992 Oct;11(10):3541-9. doi: 10.1002/j.1460-2075.1992.tb05437.x.
9
Role and regulation of interleukin (IL)-2 receptor alpha and beta chains in IL-2-driven B-cell growth.白细胞介素（IL）-2受体α链和β链在IL-2驱动的B细胞生长中的作用及调控
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3551-5. doi: 10.1073/pnas.89.8.3551.

本文引用的文献

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Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor.胰岛素刺激其自身受体95,000道尔顿亚基的磷酸化。
Science. 1982 Jan 8;215(4529):185-7. doi: 10.1126/science.7031900.
2
T cell growth factor receptors. Quantitation, specificity, and biological relevance.T细胞生长因子受体。定量、特异性及生物学相关性。
J Exp Med. 1981 Nov 1;154(5):1455-74. doi: 10.1084/jem.154.5.1455.
3
A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.一种与活化且功能成熟的人T细胞反应的单克隆抗体（抗Tac）。I. 抗Tac单克隆抗体的产生及Tac（+）细胞的分布。
J Immunol. 1981 Apr;126(4):1393-7.
4
Properties of human interleukin-2 receptors expressed on non-lymphoid cells by cDNA transfection.通过cDNA转染在非淋巴细胞上表达的人白细胞介素-2受体的特性
Mol Biol Med. 1984 Dec;2(6):379-96.
5
Interleukin 2.白细胞介素2
Annu Rev Immunol. 1984;2:319-33. doi: 10.1146/annurev.iy.02.040184.001535.
6
A rat monoclonal antibody that binds specifically to mouse T lymphoblasts and inhibits IL 2 receptor functions: a putative anti-IL 2 receptor antibody.一种能特异性结合小鼠T淋巴母细胞并抑制白细胞介素2受体功能的大鼠单克隆抗体：一种假定的抗白细胞介素2受体抗体。
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Structure and expression of a cloned cDNA for human interleukin-2.人白细胞介素-2克隆cDNA的结构与表达
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8
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.人表皮生长因子受体cDNA序列及扩增基因在A431表皮样癌细胞中的异常表达。
Nature. 1984;309(5967):418-25. doi: 10.1038/309418a0.
9
Characterization of human interleukin 2 receptor (Tac antigen) in normal and leukemic T cells: co-expression of normal and aberrant receptors on Hut-102 cells.正常和白血病T细胞中人白细胞介素2受体（Tac抗原）的特性：Hut-102细胞上正常受体与异常受体的共表达
J Immunol. 1984 Jun;132(6):3005-10.
10
Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta.胰岛素受体是一种依赖胰岛素的酪氨酸蛋白激酶：从人胎盘中将胰岛素结合活性和蛋白激酶活性共纯化至同质。
Proc Natl Acad Sci U S A. 1984 Jun;81(11):3327-31. doi: 10.1073/pnas.81.11.3327.

白细胞介素2受体的跨膜信号传导。人白细胞介素2受体（p55）/胰岛素受体嵌合分子的构象与功能。

Transmembrane signaling of interleukin 2 receptor. Conformation and function of human interleukin 2 receptor (p55)/insulin receptor chimeric molecules.

作者信息

Hatakeyama M, Doi T, Kono T, Maruyama M, Minamoto S, Mori H, Kobayashi M, Uchiyama T, Taniguchi T

出版信息

J Exp Med. 1987 Aug 1;166(2):362-75. doi: 10.1084/jem.166.2.362.

DOI:10.1084/jem.166.2.362
PMID:3110352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189584/
Abstract

Chimeric genes were constructed which gave rise to the expression of novel receptor molecules consisting of the extracellular domain of the human interleukin 2 receptor (IL-2-R; p55 or Tac antigen) joined to the transmembrane domain and either full-length or truncated cytoplasmic domain of the human insulin receptor (Ins-R). Expression studies using mouse T cell line EL-4 revealed that the chimeric receptors are able to manifest properties indistinguishable from the authentic IL-2-R. On the other hand, stimulation of the tyrosine kinase activity by IL-2 was not observed in the chimeric receptor with the entire cytoplasmic domain of the Ins-R. These findings thus shed light on the structural conformation and functioning of the IL-2-R complex.

摘要

构建了嵌合基因，其导致由人白细胞介素2受体（IL-2-R；p55或Tac抗原）的细胞外结构域与跨膜结构域以及人胰岛素受体（Ins-R）的全长或截短细胞质结构域连接而成的新型受体分子的表达。使用小鼠T细胞系EL-4进行的表达研究表明，嵌合受体能够表现出与天然IL-2-R无法区分的特性。另一方面，在具有Ins-R整个细胞质结构域的嵌合受体中未观察到IL-2对酪氨酸激酶活性的刺激。因此，这些发现揭示了IL-2-R复合物的结构构象和功能。