Université Grenoble Alpes - INSERM U1209 - CNRS UMR 5309, 38000 Grenoble, France.
J Mater Chem B. 2020 Mar 18;8(11):2216-2232. doi: 10.1039/c9tb02767j.
In parallel with the rapidly growing and widespread use of nanomedicine in the clinic, we are also witnessing the development of so-called theranostic agents that combine diagnostic and therapeutic properties. Among them, ultra-small gold nanoclusters (Au NCs) show promising potential due to their optical properties and activatable therapeutic activities under irradiation. Furthermore, due to their hydrodynamic diameter of smaller than 6 nm and unique biophysical properties, they also present intriguing behaviors in biological and physio-pathological environments. In this review, we aim to present the latest research studies published on such nanoparticles in animals. We also propose guidelines to identify the main physico-chemical parameters that govern the behaviour of Au NCs after administration in small animals, notably concerning their renal elimination and their ability to accumulate in tumors. Then, we present recent advances in their use as theranostic agents putting them in parallel with other contrast agents.
随着纳米医学在临床上的快速发展和广泛应用，我们也见证了所谓的治疗诊断一体化试剂的发展，这些试剂结合了诊断和治疗特性。在这些试剂中，超小金纳米团簇（Au NCs）由于其在辐照下的光学性质和可激活的治疗活性而显示出有前途的潜力。此外，由于其水动力学直径小于 6nm 且具有独特的物理化学性质，它们在生物和生理病理环境中也表现出有趣的行为。在这篇综述中，我们旨在介绍已在动物身上发表的关于此类纳米颗粒的最新研究。我们还提出了一些准则，以确定主要的物理化学参数，这些参数可以控制 Au NCs 在小动物体内给药后的行为，特别是它们的肾脏排泄和在肿瘤中积累的能力。然后，我们介绍了将它们与其他对比剂并置作为治疗诊断一体化试剂的最新进展。
