血期疟原虫抗原：结构、功能和疫苗潜力。

Blood-Stage Malaria Parasite Antigens: Structure, Function, and Vaccine Potential.

机构信息

Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD,, 20892, USA.

出版信息

J Mol Biol. 2019 Oct 4;431(21):4259-4280. doi: 10.1016/j.jmb.2019.05.018. Epub 2019 May 17.

DOI:10.1016/j.jmb.2019.05.018

PMID:31103771

Abstract

Plasmodium parasites are the causative agent of malaria, a disease that kills approximately 450,000 individuals annually, with the majority of deaths occurring in children under the age of 5 years and the development of a malaria vaccine is a global health priority. Plasmodium parasites undergo a complex life cycle requiring numerous diverse protein families. The blood stage of parasite development results in the clinical manifestation of disease. A vaccine that disrupts the blood stage is highly desired and will aid in the control of malaria. The blood stage comprises multiple steps: invasion of, asexual growth within, and egress from red blood cells. This review focuses on blood-stage antigens with emphasis on antigen structure, antigen function, neutralizing antibodies, and vaccine potential.

摘要

疟原虫是疟疾的病原体，每年导致约 45 万人死亡，其中大多数死亡发生在 5 岁以下儿童中，因此开发疟疾疫苗是全球卫生的重点。疟原虫经历复杂的生命周期，需要多种不同的蛋白质家族。寄生虫的血液阶段导致疾病的临床表现。一种能破坏血液阶段的疫苗是非常需要的，将有助于控制疟疾。血液阶段包括多个步骤：侵入、在红细胞内无性生长和从红细胞逸出。这篇综述重点介绍了血液阶段抗原，强调了抗原结构、抗原功能、中和抗体和疫苗潜力。