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恶性疟原虫富含半胱氨酸的红细胞膜蛋白A（PfCyRPA）上的一个可靶向的受体结合位点，有助于抗击疟疾。

A targetable receptor-binding site on PfCyRPA to aid in the fight against malaria.

作者信息

Dickey Thayne H, Tolia Niraj H

机构信息

Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20894, USA.

Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20894, USA.

出版信息

Trends Parasitol. 2024 May;40(5):367-368. doi: 10.1016/j.pt.2024.04.001. Epub 2024 Apr 10.

DOI:10.1016/j.pt.2024.04.001
PMID:38604871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11065576/
Abstract

Recently, Day et al. identified a receptor-binding site on the malaria parasite protein PfCyRPA that binds the host sugar Neu5Ac, and they found that disrupting this interaction impedes parasite growth. A map of the receptor-binding site identifies an attractive target for antimalarial vaccines and therapeutics.

摘要

最近，戴等人在疟原虫蛋白PfCyRPA上鉴定出一个与宿主糖Neu5Ac结合的受体结合位点，并且他们发现破坏这种相互作用会阻碍疟原虫的生长。受体结合位点图谱为抗疟疫苗和治疗药物确定了一个有吸引力的靶点。

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本文引用的文献

1
The essential malaria protein PfCyRPA targets glycans to invade erythrocytes.疟原虫关键蛋白 PfCyRPA 以糖基为靶标入侵红细胞。
Cell Rep. 2024 Apr 23;43(4):114012. doi: 10.1016/j.celrep.2024.114012. Epub 2024 Apr 3.
2
The PfRCR complex bridges malaria parasite and erythrocyte during invasion.PfRCR 复合物在入侵过程中介导疟原虫和红细胞。
Nature. 2024 Jan;625(7995):578-584. doi: 10.1038/s41586-023-06856-1. Epub 2023 Dec 20.
3
PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum.PCRCR 复合物对于恶性疟原虫入侵人类红细胞是必不可少的。
Nat Microbiol. 2022 Dec;7(12):2039-2053. doi: 10.1038/s41564-022-01261-2. Epub 2022 Nov 17.
4
Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A.针对 PfRipr 短区域的抗体可抑制恶性疟原虫裂殖子入侵以及 PfRipr 与 Rh5 和 SEMA7A 的相互作用。
Sci Rep. 2020 Apr 20;10(1):6573. doi: 10.1038/s41598-020-63611-6.
5
Functional Comparison of Blood-Stage Malaria Vaccine Candidate Antigens.血期疟疾疫苗候选抗原的功能比较。
Front Immunol. 2019 Jun 4;10:1254. doi: 10.3389/fimmu.2019.01254. eCollection 2019.
6
Blood-Stage Malaria Parasite Antigens: Structure, Function, and Vaccine Potential.血期疟原虫抗原：结构、功能和疫苗潜力。
J Mol Biol. 2019 Oct 4;431(21):4259-4280. doi: 10.1016/j.jmb.2019.05.018. Epub 2019 May 17.
7
Structural basis for inhibition of erythrocyte invasion by antibodies to protein CyRPA.抗CyRPA蛋白抗体抑制红细胞入侵的结构基础
Elife. 2017 Feb 14;6:e21347. doi: 10.7554/eLife.21347.
8
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody.疟疾疫苗候选抗原CyRPA的结构及其与寄生虫入侵抑制抗体的复合物
Elife. 2017 Feb 14;6:e20383. doi: 10.7554/eLife.20383.
9
Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen.经感染疟原虫的小鼠实验证实，CyRPA 可作为候选疟疾疫苗抗原发挥被动免疫保护作用。
J Immunol. 2012 Jun 15;188(12):6225-37. doi: 10.4049/jimmunol.1103177. Epub 2012 May 16.