Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada.
Ultrasound Med Biol. 2019 Aug;45(8):1918-1923. doi: 10.1016/j.ultrasmedbio.2019.03.013. Epub 2019 May 17.
The purpose of this study was to quantify the stiffness of hypertrophic scars using acoustic radiation force impulse ultrasound elastography. Sixteen pediatric patients with hypertrophic scars resulting from burn injuries participated in this study (mean age: 5.13, standard deviation: 3.20). Values for the elastic modulus (E) of scar and control sites were obtained. Scarred areas were found to be almost four times stiffer than control sites (scar E = 39.29 kPa compared with control E = 10.19 kPa) (p = 0.0004). Correlations between scar stiffness and clinician-reported subjective scar scale scores were not observed (r = 0.30, p = 0.27 and r = 0.25, p = 0.35 respectively). We found that acoustic radiation force impulse imaging can discriminate between hypertrophic scars and normal skin and should be considered a potentially valuable tool in the armamentarium of objective scar measures. Future research should focus on evaluating the technology's ability to detect scar change over time in order to determine responsiveness to treatment.
本研究旨在使用声辐射力脉冲超声弹性成像量化增生性瘢痕的硬度。16 名因烧伤导致增生性瘢痕的儿科患者参与了本研究（平均年龄：5.13，标准差：3.20）。获得了瘢痕和对照部位的弹性模量（E）值。结果发现，瘢痕区域的硬度几乎是对照区域的四倍（瘢痕 E=39.29kPa，对照 E=10.19kPa）（p=0.0004）。瘢痕硬度与临床医生报告的主观瘢痕量表评分之间没有观察到相关性（r=0.30，p=0.27 和 r=0.25，p=0.35）。我们发现，声辐射力脉冲成像可以区分增生性瘢痕和正常皮肤，应该被视为客观瘢痕测量的一种潜在有价值的工具。未来的研究应集中评估该技术检测瘢痕随时间变化的能力，以确定其对治疗的反应性。
Ultrasound Med Biol. 2019-5-17
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