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弹性模量与病理性瘢痕临床严重程度的相关性:一项横断面研究。

Correlation between elastic modulus and clinical severity of pathological scars: a cross-sectional study.

机构信息

Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Department of Ultrasound, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210029, China.

出版信息

Sci Rep. 2021 Dec 2;11(1):23324. doi: 10.1038/s41598-021-02730-0.


DOI:10.1038/s41598-021-02730-0
PMID:34857833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8639709/
Abstract

Though widely used to assess pathological scars, the modified Vancouver Scar Scale (mVSS) is neither convenient nor objective. Shear wave elastography (SWE) is used to evaluate the stiffness of pathological scars. We aimed to determine the correlation between mVSS score and elastic modulus (EM) measured by SWE for pathological scars. Clinical information including ultrasound (US) results of the enrolled patients with pathological scars was analyzed. The clinical severity of the pathological scars was evaluated by mVSS. Skin stiffness, as represented by EM, was calculated using SWE. The average EM of the whole scar (EM), hardest part of the scar (EM), and normal appearance of the skin around the scar (EM) were also recorded. Enrolled in this study were 69 pathological scars, including 28 hypertrophic scars and 41 keloids. The univariable regression analyses showed that the EM of pathological scars was closely related to mVSS score, while the linear multivariable regression analyses showed no significantly correlation. Curve fitting and threshold effect analysis revealed that when EM was less than 166.6 kPa or EM was less than 133.07 kPa, EM was positively correlated with mVSS score. In stratified analysis, there was no significant linear correlation and threshold effect between EM and mVSS score in hypertrophic scars or keloids. However, the fully adjusted smooth curves presented a linear association between mVSS score and EM in keloids (the adjusted β [95% CI] was 0.010 [0.001, 0.018]), but a threshold and nonlinear association were found in hypertrophic scars. When EM was less than 156.13 kPa, the mVSS score increased along with the hardest scar part stiffness; the adjusted β (95% CI) was 0.024 (0.009, 0.038). In conclusion, EM of pathological scars measured by SWE were correlated with mVSS within a threshold range, and showed different association patterns in hypertrophic scars and keloids.

摘要

尽管改良温哥华瘢痕量表 (mVSS) 被广泛用于评估病理性瘢痕,但它既不方便也不客观。剪切波弹性成像 (SWE) 用于评估病理性瘢痕的硬度。我们旨在确定 mVSS 评分与 SWE 测量的病理性瘢痕弹性模量 (EM) 之间的相关性。分析了纳入病理性瘢痕患者的临床信息,包括超声 (US) 结果。采用 mVSS 评估病理性瘢痕的临床严重程度。使用 SWE 计算皮肤硬度,代表 EM。还记录了整个瘢痕的平均 EM(EM)、瘢痕最硬部分的 EM(EM)和瘢痕周围正常皮肤的 EM(EM)。本研究共纳入 69 例病理性瘢痕,其中 28 例为增生性瘢痕,41 例为瘢痕疙瘩。单变量回归分析显示,病理性瘢痕的 EM 与 mVSS 评分密切相关,而线性多变量回归分析显示无显著相关性。曲线拟合和阈值效应分析表明,当 EM 小于 166.6 kPa 或 EM 小于 133.07 kPa 时,EM 与 mVSS 评分呈正相关。在分层分析中,增生性瘢痕或瘢痕疙瘩的 EM 与 mVSS 评分之间无显著线性关系和阈值效应。然而,在瘢痕疙瘩中,经过完全调整的平滑曲线显示 mVSS 评分与 EM 之间存在线性关联(调整后的 β[95%CI]为 0.010[0.001, 0.018]),而在增生性瘢痕中则存在阈值和非线性关联。当 EM 小于 156.13 kPa 时,随着最硬瘢痕部分硬度的增加,mVSS 评分增加;调整后的 β(95%CI)为 0.024(0.009, 0.038)。总之,SWE 测量的病理性瘢痕的 EM 在阈值范围内与 mVSS 相关,在增生性瘢痕和瘢痕疙瘩中表现出不同的关联模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/3b0c2e1a80fc/41598_2021_2730_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/d0efc98a8a4d/41598_2021_2730_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/23c16e4b64fa/41598_2021_2730_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/4d1b2ffa21f0/41598_2021_2730_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/20681cd2a04b/41598_2021_2730_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/8d5ef7a3f916/41598_2021_2730_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/5c5b8ad3cf80/41598_2021_2730_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/5ce4eea86995/41598_2021_2730_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/3b0c2e1a80fc/41598_2021_2730_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/d0efc98a8a4d/41598_2021_2730_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/23c16e4b64fa/41598_2021_2730_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/4d1b2ffa21f0/41598_2021_2730_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/20681cd2a04b/41598_2021_2730_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/8d5ef7a3f916/41598_2021_2730_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/5c5b8ad3cf80/41598_2021_2730_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/5ce4eea86995/41598_2021_2730_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a921/8639709/3b0c2e1a80fc/41598_2021_2730_Fig8_HTML.jpg

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本文引用的文献

[1]
Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation.

Biomed Pharmacother. 2020-9

[2]
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Burns. 2020-12

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Ultrasound Med Biol. 2020-5

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Quantification of skin lesions using high-frequency ultrasound and shear wave elastography in port-wine stain patients: a clinical study.

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Reappraisal of shear wave elastography as a diagnostic tool for identifying thyroid carcinoma.

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High-resolution ultrasound for keloids and hypertrophic scar assessment.

Lasers Med Sci. 2019-6-25

[7]
Hypertrophic and keloid scars fail to progress from the CD34 /α-smooth muscle actin (α-SMA) immature scar phenotype and show gradient differences in α-SMA and p16 expression.

Br J Dermatol. 2020-4

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Quantification of Pediatric Burn Scar Stiffness Using Acoustic Radiation Force Impulse Ultrasound Elastography.

Ultrasound Med Biol. 2019-5-17

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