Sommer Andrei P
Ulm, Baden-Württemberg, Germany.
Photobiomodul Photomed Laser Surg. 2019 Jun;37(6):336-341. doi: 10.1089/photob.2018.4606. Epub 2019 May 20.
Several reports claim that the enzyme cytochrome c oxidase (CCO) is the primary absorber for red-to-near-infrared (R-NIR) light in cells and causal for mitochondrial adenosine triphosphate (ATP) upregulation, and that pulsed R-NIR light has frequent therapeutic effects, which are superior to those of the continuous wave (CW) mode used in low-level light therapy (LLLT). Convincing evidence that the absorption of R-NIR photons by CCO is involved in mitochondrial ATP upregulations as well as a coherent explanation for the superiority of the pulsed irradiation mode is presently lacking in the literature. A comprehensive literature search and rigorous analysis of the data published on the idea that CCO is the primary absorber for R-NIR light, and of the claim that the effectivity of the pulsed irradiation mode can be derived from the absorption of R-NIR photons by CCO, reveal a number of severe inconsistencies. A systematical analysis covering both the theory that CCO is the primary acceptor for R-NIR light and of its use to interpret differences between the biological effect of pulsed light and CW casts doubt on the general validity of the CCO-based hypothesis. Instead, we are offered a simple and conflict-free model accounting for both ATP upregulation and superiority of the pulsed mode in LLLT, which is in agreement with the results of recent laboratory experiments. CCO is not the primary acceptor for R-NIR light.
几份报告称，细胞色素c氧化酶（CCO）是细胞中红到近红外（R-NIR）光的主要吸收体，也是线粒体三磷酸腺苷（ATP）上调的原因，并且脉冲R-NIR光具有频繁的治疗效果，优于低强度光疗法（LLLT）中使用的连续波（CW）模式。目前文献中缺乏令人信服的证据表明CCO对R-NIR光子的吸收与线粒体ATP上调有关，也缺乏对脉冲照射模式优越性的连贯解释。对已发表的关于CCO是R-NIR光主要吸收体这一观点的数据，以及关于脉冲照射模式的有效性可源于CCO对R-NIR光子的吸收这一说法进行全面的文献检索和严格分析，发现了许多严重的不一致之处。对CCO是R-NIR光主要受体的理论及其用于解释脉冲光和连续波光生物学效应差异的系统分析，对基于CCO的假设的普遍有效性提出了质疑。相反，我们提出了一个简单且无冲突的模型，该模型既能解释ATP上调，又能解释LLLT中脉冲模式的优越性，这与最近实验室实验的结果一致。CCO不是R-NIR光的主要受体。
