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氯化锶与光生物调节联合用于控制牙齿漂白后敏感:一项半口随机临床试验。

Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching: A split-mouth randomized clinical trial.

作者信息

Pompeu Danielle da Silva, de Paula Brennda Lucy Freitas, Barros Antônia Patricia Oliveira, Nunes Samir Costa, Carneiro Alexandra Melo Pingarilho, Araújo Jesuína Lamartine Nogueira, Silva Cecy Martins

机构信息

School of Dentistry, Federal University of Pará, Belem, Brazil.

Postgraduate Program in Dentistry of the Federal University of Pará, Belem, Brazil.

出版信息

PLoS One. 2021 Apr 28;16(4):e0250501. doi: 10.1371/journal.pone.0250501. eCollection 2021.

Abstract

OBJECTIVE

This split-mouth randomized controlled clinical trial assessed the effect of 10% strontium chloride in combination with photobiomodulation (PBM) for the control of tooth sensitivity (TS) post-bleaching.

METHODS

The upper/lower, right and left quadrants of fifty volunteers were randomized and allocated to four groups (n = 25): PLACEBO-placebo gel + simulation of PBM; Placebo + PBM; STRONTIUM-10% strontium chloride + simulation of PBM; and PBM + STRONTIUM-10% strontium chloride + PBM. All groups received tooth bleaching treatment with 35% hydrogen peroxide. For the PBM treatment, the laser tip was positioned in the apical and cervical regions of the teeth bleached in the respective hemi-arch. The laser system was operated in continuous mode, using 1.7 J of energy. A dose of 60 J/cm2 was applied to each point for 16 seconds under 808 nm near-infrared light (100mW of power), with a point area of 0.028 cm2. TS was assessed during a 21-day follow-up, using the modified visual analogue scale.

RESULTS

In the intragroup assessment, the Friedman test indicated that PBM + STRONTIUM promoted the greatest reduction in TS after the second week of treatment (p ≤ 0.05). The Wilcoxon-Mann-Whitney test indicated that the groups Placebo + PBM, STRONTIUM, and STRONTIUM + PBM did not differ statistically (p ≥ 0.05) in the first and third weeks of treatment The group PLACEBO exhibited the greatest TS in the first three days after each bleaching session.

CONCLUSION

The combination of 10% strontium chloride with PBM was effective in reducing post-bleaching TS; however, the combination of 10% strontium chloride with PBM was effective in reducing post-bleaching TS; however, it did not differ from the individual use of Placebo + PBM or STRONTIUM groups assessed after 21 days of follow-up.

摘要

目的

本双盲随机对照临床试验评估了10%氯化锶联合光生物调节作用(PBM)对控制牙齿漂白后牙齿敏感(TS)的效果。

方法

五十名志愿者的上下、左右象限被随机分配到四组(n = 25):安慰剂组-安慰剂凝胶+模拟PBM;安慰剂+PBM;锶组-10%氯化锶+模拟PBM;以及PBM+锶组-10%氯化锶+PBM。所有组均接受35%过氧化氢牙齿漂白治疗。对于PBM治疗,将激光头置于相应半牙弓漂白牙齿的根尖和颈部区域。激光系统以连续模式运行,使用1.7焦耳能量。在808纳米近红外光(功率100毫瓦)下,以0.028平方厘米的点面积,对每个点施加60焦耳/平方厘米的剂量,持续16秒。在21天的随访期间,使用改良视觉模拟量表评估TS。

结果

在组内评估中,弗里德曼检验表明,PBM+锶组在治疗第二周后TS降低幅度最大(p≤0.05)。威尔科克森-曼-惠特尼检验表明,安慰剂+PBM组、锶组和锶+PBM组在治疗第一周和第三周无统计学差异(p≥0.05)。安慰剂组在每次漂白疗程后的前三天TS最高。

结论

10%氯化锶与PBM联合使用对降低漂白后TS有效;然而,10%氯化锶与PBM联合使用对降低漂白后TS有效;然而,在随访21天后,它与单独使用安慰剂+PBM组或锶组相比无差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a09/8081218/d221fdfe048f/pone.0250501.g001.jpg

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