Division of Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
Department of Respiratory Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan.
J Clin Invest. 2019 May 20;129(7):2619-2628. doi: 10.1172/JCI124615.
Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophage function is a sum of their ontogeny, the local environment in which they reside, and the type of injuries or pathogen to which they are exposed. In this Review, we discuss the role of macrophages in the restoration of tissue function after injury, highlighting important questions about how they respond to and modify the local microenvironment to restore homeostasis.
巨噬细胞是组织驻留细胞或浸润免疫细胞，对于先天免疫、正常组织发育、内稳态和受损组织修复至关重要。巨噬细胞的功能是其个体发生、所处的局部环境以及所暴露于的损伤或病原体类型的总和。在这篇综述中，我们讨论了巨噬细胞在损伤后组织功能恢复中的作用，强调了它们如何响应和改变局部微环境以恢复内稳态的重要问题。
