Gay Camille, Perrin Jeanne, Courbiere Blandine, Bretelle Florence, Agostini Aubert
Clinico-Biological Center of Medical Assistance for Procreation, AP-HM La Conception, 147 bd Baille, 13005, Marseille, France.
Clinico-Biological Center of Medical Assistance for Procreation, AP-HM La Conception, 147 bd Baille, 13005, Marseille, France; Aix Marseille Université, CNRS, IRD, Avignon Université, IMBE UMR 7263, 13397, Marseille, France.
J Gynecol Obstet Hum Reprod. 2019 Nov;48(9):727-730. doi: 10.1016/j.jogoh.2019.05.009. Epub 2019 May 17.
Ovarian reserve is a major prognosic factor for Medical Assisted Procreation. Tubal surgery, realised close to mesosalpinx and ovarian vascularization, could impare ovarian function. However, salpingectomy is currently used to treat ectopic pregnancies or hydrosalpinx before IVF attempt. Disponible studies on this subject are unclear. The aim of this study is to evaluate the impact of salpingectomy for ectopic pregnancy on the ovarian response during IVF attempt.
It was a single center comparative study. Included patients were the one receiving oocyte puncture for IVF attempt, with a history of unilateral tubal surgery: salpingectomy for ectopic pregnancy. We conducted a case-control study, comparing the sonographic parameters of the surgery ovary (case) to those of the safe ovary (control) during the first IVF attempt after salpingectomy. The ovarian sonographic response was evaluated according to the follicular antral count on day 3 and the sonographic follicular count on trigger day.
55 patients were included. There was no significant difference in the number of recruited follicles on the operated side versus control side (p = 0.85 for >14 mm follicles, p = 0,46 for 10 to 14 mm, p = 0,52 for total amount of recruited follicles). There was no significant difference for the follicular antral count neither (p = 0.79).
In our population, there was no significant difference in the sonographic ovarian response to IVF stimulation between the ovary on the operated side and the control ovary among patients treated by unilateral salpingectomy for ectopic pregnancy.
卵巢储备是辅助生殖的一个主要预后因素。靠近输卵管系膜和卵巢血管进行的输卵管手术可能会损害卵巢功能。然而，目前输卵管切除术用于在体外受精（IVF）尝试前治疗异位妊娠或输卵管积水。关于这一主题的现有研究并不明确。本研究的目的是评估异位妊娠输卵管切除术对IVF尝试期间卵巢反应的影响。
这是一项单中心对照研究。纳入的患者是接受IVF尝试卵母细胞穿刺且有单侧输卵管手术史（因异位妊娠行输卵管切除术）的患者。我们进行了一项病例对照研究，比较输卵管切除术后首次IVF尝试期间手术侧卵巢（病例）与对侧卵巢（对照）的超声参数。根据第3天的窦卵泡计数和扳机日的超声卵泡计数评估卵巢超声反应。
纳入55例患者。手术侧与对照侧募集卵泡数量无显著差异（直径>14mm卵泡，p = 0.85；10至14mm卵泡，p = 0.46；募集卵泡总数，p = 0.52）。窦卵泡计数也无显著差异（p = 0.79）。
在我们的研究人群中，对于因异位妊娠接受单侧输卵管切除术的患者，手术侧卵巢与对照卵巢对IVF刺激的超声卵巢反应无显著差异。
