Columbia University, New York, New York (B.L., W.K.C.).
Ann Intern Med. 2019 Jun 4;170(11):796-804. doi: 10.7326/M18-2357. Epub 2019 May 21.
Pharmacogenetics may help physicians deliver individualized treatments based on how a person's genes affect a drug's effects and metabolism. This information can help prevent adverse events or improve drug efficacy by enabling the physician to optimize dosage or to avoid a medication with adverse reactions and to prescribe an alternative therapy. This article discusses the current clinical utility of pharmacogenetic testing in the context of a patient who requires anticoagulation with warfarin.
药物遗传学可以帮助医生根据一个人的基因如何影响药物的作用和代谢来提供个体化治疗。这些信息可以通过使医生优化剂量或避免使用有不良反应的药物并开替代疗法来帮助预防不良事件或提高药物疗效。本文讨论了在需要华法林抗凝的患者背景下,药物遗传学检测的当前临床实用性。