Department of Ophthalmology, the Icahn School of Medicine at Mount Sinai, New York, New York, United States.
Department of Medicine, the Icahn School of Medicine at Mount Sinai, New York, New York, United States.
Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2218-2225. doi: 10.1167/iovs.18-26070.
To evaluate relationships among retinal vascular caliber and biomarkers of systemic inflammation in patients with AIDS.
A total of 454 participants with AIDS had retinal vascular caliber (central retinal artery equivalent and central retinal vein equivalent) determined from enrollment retinal photographs by reading center graders masked to clinical and biomarker information. Cryopreserved plasma specimens were assayed for inflammatory biomarkers, including C-reactive protein (CRP), IL-6, interferon-γ inducible protein (IP)-10, kynurenine/tryptophan (KT) ratio, and intestinal fatty acid binding protein (I-FABP).
In the simple linear regression of retinal vascular caliber on plasma biomarkers, elevated CRP, IL-6, and IP-10 were associated with retinal venular dilation, and elevated KT ratio with retinal arteriolar narrowing. In the multiple linear regression, including baseline characteristics and plasma biomarkers, AMD was associated with dilation of retinal arterioles (mean difference: 9.1 μm; 95% confidence interval [CI] 5.2, 12.9; P < 0.001) and venules (mean difference, 10.9 μm; 95% CI, 5.3, 16.6; P < 0.001), as was black race (P < 0.001). Hyperlipidemia was associated with retinal venular narrowing (mean difference, -7.5 μm; 95% CI, -13.7, -1.2; P = 0.02); cardiovascular disease with arteriolar narrowing (mean difference, -5.2 μm; 95% CI, -10.3, -0.1; P = 0.05); age with arteriolar narrowing (slope, -0.26 μm/year; 95% CI, -0.46, -0.06; P = 0.009); and IL-6 with venular dilation (slope, 5.3 μm/standard deviation log10[plasma IL-6 concentration]; 95% CI, 2.7, 8.0; P < 0.001).
These data suggest that retinal vascular caliber is associated with age, race, AMD, hyperlipidemia, cardiovascular disease, and selected biomarkers of systemic inflammation.
评估艾滋病患者视网膜血管口径与全身炎症生物标志物之间的关系。
共有 454 名艾滋病患者的视网膜血管口径（视网膜中央动脉当量和视网膜中央静脉当量）由读片中心评估员从入组时的视网膜照片中确定，这些评估员对临床和生物标志物信息进行了盲法评估。冷冻保存的血浆标本用于检测炎症生物标志物，包括 C 反应蛋白（CRP）、白细胞介素 6（IL-6）、干扰素诱导蛋白 10（IP-10）、犬尿氨酸/色氨酸（KT）比值和肠脂肪酸结合蛋白（I-FABP）。
在视网膜血管口径与血浆生物标志物的简单线性回归中，CRP、IL-6 和 IP-10 水平升高与视网膜静脉扩张有关，而 KT 比值升高与视网膜小动脉狭窄有关。在包括基线特征和血浆生物标志物的多元线性回归中，AMD 与视网膜小动脉扩张（平均差异：9.1μm；95%置信区间[CI]，5.2，12.9；P<0.001）和视网膜小静脉扩张（平均差异，10.9μm；95%CI，5.3，16.6；P<0.001）相关，黑种人（P<0.001）也是如此。高脂血症与视网膜小静脉变窄有关（平均差异，-7.5μm；95%CI，-13.7，-1.2；P=0.02）；心血管疾病与小动脉狭窄有关（平均差异，-5.2μm；95%CI，-10.3，-0.1；P=0.05）；年龄与小动脉狭窄有关（斜率，-0.26μm/年；95%CI，-0.46，-0.06；P=0.009）；IL-6 与小静脉扩张有关（斜率，5.3μm/标准偏差对数 10[血浆 IL-6 浓度]；95%CI，2.7，8.0；P<0.001）。
这些数据表明，视网膜血管口径与年龄、种族、AMD、高脂血症、心血管疾病和全身炎症的某些生物标志物有关。
