Visco Annamaria, Scolaro Cristina, Giamporcaro Alberto, De Caro Salvatore, Tranquillo Elisabetta, Catauro Michelina
Department of Engineering, University of Messina, C.da Di Dio, 98166 Messina, Italy.
Institute for Chemical-Physical Processes CNR ⁻IPCF, Viale Ferdinando Stagno d'Alcontres, 37, 98158 Messina, Italy.
Polymers (Basel). 2019 May 17;11(5):901. doi: 10.3390/polym11050901.
Poly (Lactic Acid), PLA, and Poly (ε-CaproLactone), PCL, compatibilized with Ethyl Ester l-Lysine Triisocyanate (LTI) can be employed as biomaterials. We mixed PLA with PCL and LTI in a twin extruder and by a melt spinning process obtained threads with an average diameter of about 0.3 mm. In order to study the possible application of these threads, mechanical tensile (with the calorimetric and morphological investigations) and biological tests were performed. The results highlighted these biopolymers as promising materials for sutures since they can be rigid and elastic (especially by increasing the PCL amount in the blend), and they are bioactive, able to inhibit bacterial growth. This paper represents a starting point to optimize the blend composition for biomedical suture application.
聚乳酸（PLA）和聚己内酯（PCL）与乙基酯 -L-赖氨酸三异氰酸酯（LTI）相容后可作为生物材料使用。我们在双螺杆挤出机中将PLA与PCL和LTI混合，并通过熔融纺丝工艺获得了平均直径约为0.3毫米的纤维。为了研究这些纤维的可能应用，我们进行了机械拉伸（同时进行量热和形态学研究）和生物学测试。结果表明，这些生物聚合物是用于缝合线的有前景的材料，因为它们可以兼具刚性和弹性（特别是通过增加共混物中PCL的含量），并且具有生物活性，能够抑制细菌生长。本文是优化生物医学缝合线应用共混物组成的起点。
