Catauro Michelina, Tranquillo Elisabetta, Barrino Federico, Blanco Ignazio, Dal Poggetto Francesco, Naviglio Daniele
Department of Engineering, University of Campania "Luigi Vanvitelli", via Roma 29, I-81031 Aversa, Italy.
Department of Civil Engineering and Architecture and UdR-Catania Consorzio INSTM, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy.
Materials (Basel). 2018 Nov 14;11(11):2270. doi: 10.3390/ma11112270.
The use of oral iron integration is commonly recommended for the treatment of iron deficiency, nevertheless the diagnosis and treatment of this disease could clearly be improved. The aim of this work was the synthesis of therapeutic systems, iron (II) based, by sol-gel method. In an SiO₂ matrix, we embedded different weight percentages of polyethylene glycol (PEG) and ferrous citrate (Fe(II)C) for drug delivery applications. Fourier Transform Infrared (FTIR) spectroscopy was used to study the interactions among different components in the hybrid materials. Release kinetics in a simulated body fluid (SBF) were investigated and the amount of Fe released was detected by Ultraviolet⁻Visible spectroscopy (UV-VIS) after reaction with ortho-phenantroline. Furthermore, the biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated by the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using FTIR spectroscopy. Finally, also, the potential antibacterial properties of the different materials against two different bacteria, and , were investigated.
口服铁剂常用于缺铁性疾病的治疗，然而，该疾病的诊断和治疗仍有明显的改进空间。本研究旨在通过溶胶-凝胶法合成基于铁（II）的治疗体系。在二氧化硅基质中，我们嵌入了不同重量百分比的聚乙二醇（PEG）和柠檬酸亚铁（Fe(II)C）用于药物递送应用。利用傅里叶变换红外光谱（FTIR）研究了杂化材料中不同组分之间的相互作用。研究了在模拟体液（SBF）中的释放动力学，并通过与邻菲罗啉反应后用紫外可见光谱（UV-VIS）检测铁的释放量。此外，还进行了生物学表征。通过FTIR光谱法对浸泡在SBF中的样品表面形成的羟基磷灰石层进行评估，以评价合成杂化材料的生物活性。最后，还研究了不同材料对两种不同细菌的潜在抗菌性能。
