Zhou Tao, Chen Jiayi, Chen Yuhang, Xu Jiayi, Liu Sijing, Zheng Tianli, Sun Dianjianyi, Qi Lu, Xiong Jingyuan, Pei Xiaofang
Department of Public Health Laboratory Sciences, West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan Province, China.
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Evid Based Complement Alternat Med. 2019 Apr 14;2019:4643074. doi: 10.1155/2019/4643074. eCollection 2019.
() shows antiobesity effects in animal studies. However, little is known about the effect on human. The present study aimed to investigate the effect of intake on weight change in obese women and the role of gut microbiota. Thirty overweight and obese female participants (BMI ≥24 kg/m) were recruited in the current study. The participants drank 10g/d for 12 wks. Their body composition and related biomarkers were assessed. Alterations of the gut microbiota were analyzed using 16S rRNA sequencing. The primary outcome was the change in body weight. intake resulted in 2.5% weight loss over 12 wks (P<0.01). Change in body fat at 12 wk was -1.77 ± 1.19 kg (P<0.01). In addition, decreased Firmicutes-to-Bacteroidetes ratio (P=0.03), increased richness (the ACE estimator, P<0.01; the Chao1 estimator, P<0.01), and altered representative taxa of the gut microbiota were observed. , , and were higher while and were lower at 12 wk. Moreover, intervention decreased fasting glucose (P<0.01), serum leptin (P<0.01), and IL8 (P=0.02) and increased HOMA- (P<0.01). intervention moderately decreased the body weight in overweight and obese women and such effect might be due to modulation of gut microbiota.
（）在动物研究中显示出抗肥胖作用。然而，其对人类的影响却知之甚少。本研究旨在调查（某种物质）摄入量对肥胖女性体重变化的影响以及肠道微生物群的作用。本研究招募了30名超重和肥胖的女性参与者（BMI≥24kg/m²）。参与者连续12周每天饮用10克（某种物质）。评估了她们的身体成分和相关生物标志物。使用16S rRNA测序分析肠道微生物群的变化。主要结果是体重的变化。摄入（某种物质）在12周内导致体重减轻2.5%（P<0.01）。12周时体脂变化为-1.77±1.19千克（P<0.01）。此外，观察到厚壁菌门与拟杆菌门的比例降低（P=0.03），丰富度增加（ACE估计器，P<0.01；Chao1估计器，P<0.01），以及肠道微生物群的代表性分类群发生改变。在12周时，（某些细菌种类）较高而（另一些细菌种类）较低。此外，（某种物质）干预降低了空腹血糖（P<0.01）、血清瘦素（P<0.01）和白细胞介素8（P=0.02），并增加了胰岛素抵抗指数（P<0.01）。（某种物质）干预适度降低了超重和肥胖女性的体重，这种作用可能归因于肠道微生物群的调节。
