Xu Shanrong, Liu Wenqi, Gong Li, Li Xinyang, Chu Wenwen, Han Meng, Shi Shuiqin, Zhou Duoqi
College of Life Science, Anqing Normal University, Anqing, 246133, P. R. China.
Department of Clinical Laboratory, Chongqing General Hospital, Chongqing, 400014, P. R. China.
Open Life Sci. 2023 Aug 1;18(1):20220646. doi: 10.1515/biol-2022-0646. eCollection 2023.
Gut microbiota are closely related to health, and the β2-adrenergic receptor () gene is associated with gastrointestinal diseases. However, little is known about the relationship between gene polymorphisms and intestinal microbiota. In the present study, we aimed to explore the relationship between gene polymorphisms and gut microbiota in Chinese Han adolescents. Data analysis showed that the relative abundance, PICRUSt function prediction, and Chao1 and ACE indices of gut microbiota were significantly different between males and females ( < 0.05). The rs1042711 was positively associated with the relative abundance of Actinobacteria, Coriobacteriia, Bifidobacteriales, Erysipelotrichi, and Erysipelotrichales. The rs12654778 was negatively associated with Bacilli, Lactobacillales, Bacteroidaceae, and . rs1042713 was positively associated with Lactobacillales and Bifidobacteriales. The rs1042717 was positively associated with Bifidobacteriales and negatively associated with Veillonellaceae. The rs1042719 was negatively associated with Erysipelotrichi and Erysipelotrichales and positively associated with Erysipelotrichi, Erysipelotrichales, Bifidobacteriales, and Ruminococcaceae in females. The rs1801704 was positively associated with Erysipelotrichi, Erysipelotrichales, Bifidobacteriales, Actinobacteria, Coriobacteriia, and Bifidobacteriales. The rs2053044 was positively associated with Ruminococcaceae, , Firmicutes, Clostridia, Clostridiales, Bifidobacteriales, and and negatively associated with Bacilli, Lactobacillales, Lachnospiraceae, and Porphyromonadaceae ( < 0.05). These results suggested that the relative abundance, diversity, and PICRUSt function predictions of male and female gut microbiomes differ significantly and that gene polymorphisms were associated with gut microbiome abundance in Chinese Han adolescents.
肠道微生物群与健康密切相关，β2-肾上腺素能受体（）基因与胃肠道疾病有关。然而，关于该基因多态性与肠道微生物群之间的关系知之甚少。在本研究中，我们旨在探讨中国汉族青少年中该基因多态性与肠道微生物群之间的关系。数据分析表明，男性和女性肠道微生物群的相对丰度、PICRUSt功能预测以及Chao1和ACE指数存在显著差异（<0.05）。rs1042711与放线菌纲、棒状杆菌目、双歧杆菌目、丹毒丝菌纲和丹毒丝菌目相对丰度呈正相关。rs12654778与芽孢杆菌纲、乳杆菌目、拟杆菌科和呈负相关。rs1042713与乳杆菌目和双歧杆菌目呈正相关。rs1042717与双歧杆菌目呈正相关，与韦荣球菌科呈负相关。rs1042719在女性中与丹毒丝菌纲和丹毒丝菌目呈负相关，与丹毒丝菌纲、丹毒丝菌目、双歧杆菌目和瘤胃球菌科呈正相关。rs1801704与丹毒丝菌纲、丹毒丝菌目、双歧杆菌目、放线菌纲、棒状杆菌目和双歧杆菌目呈正相关。rs2053044与瘤胃球菌科、、厚壁菌门、梭菌纲、梭菌目、双歧杆菌目和呈正相关，与芽孢杆菌纲、乳杆菌目、毛螺菌科和卟啉单胞菌科呈负相关（<0.05）。这些结果表明，男性和女性肠道微生物群的相对丰度、多样性和PICRUSt功能预测存在显著差异，并且该基因多态性与中国汉族青少年肠道微生物群丰度相关。
