Chung Kyung Jin, Shim Sung-Ryul, Brown Suzana, Shim Young Sup, Park Ie Byung, Kim Khae-Hawn
Department of Urology, Gil Medical Center, Gachon University School of Medicine, Incheon, Korea.
Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.
J Exerc Rehabil. 2019 Apr 26;15(2):264-269. doi: 10.12965/jer.1938160.080. eCollection 2019 Apr.
In this study, the pattern of depressive mood in patients following radical prostatectomy (RP) for localized prostate cancer (PCa) was determined. A total of 30 patients (aged 68.03±6.1 years) who were diagnosed with localized PCa and underwent RP within 1 month entered the study. Evaluations included body mass index, prostate-specific antigen, testosterone, underlying disease, international prostate symptom score and quality of life (QoL), international index of erectile function as well as Beck depression inventory (BDI), both at the initial stage and 3 months later. Basic demographic data, laboratory results, and questionnaires were analyzed statistically. The BDI score significantly decreased 3 months after the surgery. In correlation analysis, BDI was related with the international prostate symptom score but not with the underlying disease, QoL or international index of erectile function. Body mass index was identified as one of the risk factors to decrease the probability of BDI score (≥3) significantly. Underlying disease increased the probability of BDI score. In the assessment of the correlation between BDI and each subscale, sadness, self-dislike, self-criticalness, and worth-lessness showed high correlation. In the early period, depressive mood was improved at the short-term follow-up in localized PCa patients after RP. Voiding symptoms were only related with the depressive mood, but not with other parameters, including sexual function. The depressive mood had no effect on the QoL in the early stage.
在本研究中，确定了局限性前列腺癌（PCa）患者行根治性前列腺切除术（RP）后的抑郁情绪模式。共有30例（年龄68.03±6.1岁）被诊断为局限性PCa且在1个月内行RP的患者进入研究。评估内容包括初始阶段及3个月后的体重指数、前列腺特异性抗原、睾酮、基础疾病、国际前列腺症状评分和生活质量（QoL）、国际勃起功能指数以及贝克抑郁量表（BDI）。对基本人口统计学数据、实验室检查结果和问卷进行统计学分析。术后3个月BDI评分显著降低。在相关性分析中，BDI与国际前列腺症状评分相关，但与基础疾病、QoL或国际勃起功能指数无关。体重指数被确定为显著降低BDI评分（≥3）概率的危险因素之一。基础疾病增加了BDI评分的概率。在评估BDI与各分量表的相关性时，悲伤、自我厌恶、自我批评和无价值感显示出高度相关性。在早期，局限性PCa患者行RP后短期随访时抑郁情绪得到改善。排尿症状仅与抑郁情绪相关，而与包括性功能在内的其他参数无关。早期抑郁情绪对QoL无影响。
