Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH.
Aesthet Surg J. 2020 Mar 23;40(4):NP177-NP188. doi: 10.1093/asj/sjz146.
The prevalence of hair loss, its psychological consequences, and historically subpar treatments present a unique challenge to the physician. The current Food and Drug Administration-approved treatments for hair loss are plagued by ineffectiveness, noncompliance, and adverse effects. Recent advances in our understanding of hair physiology have fueled the development of more efficacious, minimally invasive, and safer treatment options for hair restoration including plasma-rich protein and stem cell therapy. Platelet-rich plasma, the autologous preparation of concentrated platelets in plasma, when injected into the scalp of patients with both androgenetic alopecia (AGA) and alopecia areata (AA), has been shown to increase hair count and density. The clinical findings have been supported by histologic evaluation of the scalp skin. These findings have been recapitulated in numerous randomized controlled trials. Stem cell therapy, although newer in its application in hair restoration, has also been effective for treating both AGA and AA. The isolation techniques for stem cells are varied, but regardless have shown promising results in early prospective and retrospective studies.
脱发的患病率、其心理后果以及历史上欠佳的治疗方法给医生带来了独特的挑战。目前，美国食品和药物管理局批准的脱发治疗方法存在疗效不佳、不遵医嘱和不良反应等问题。我们对毛发生理学的理解的最新进展推动了更有效、微创和更安全的毛发修复治疗选择的发展，包括富含生长因子的血浆和干细胞疗法。富含血小板的血浆是将浓缩血小板自体制备于富血小板血浆中，当注射到雄激素性脱发（AGA）和斑秃（AA）患者的头皮中时，已被证明可以增加头发数量和密度。头皮皮肤的组织学评估支持了这些临床发现。这些发现已经在许多随机对照试验中得到了重复。干细胞疗法虽然在毛发修复中的应用较新，但对 AGA 和 AA 的治疗也同样有效。干细胞的分离技术多种多样，但无论哪种方法，在早期前瞻性和回顾性研究中都显示出了有前景的结果。
