2nd Neurosurgery Clinic, "Prof. Dr. N. Oblu" Emergency Clinical Hospital, Iasi, Romania.
Department of Neurosurgery, "Grigore. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
Eur Neurol. 2019;81(1-2):76-78. doi: 10.1159/000500719. Epub 2019 May 21.
King of the Spanish Habsburg dynasty and sovereign of the overseas Spanish Empire, Charles II of Spain, was physically disabled, disfigured, mentally retarded, and he proved impotent. He is known in history as El Hechizado (the Bewitched) because both him and the people believed that his mental and physical incapacity were due to a "witchcraft act." Although several authors speculated about different diseases, most of them genetic such as pituitary hormone deficiency, distal renal tubular acidosis, Klinefelter syndrome, fragile X syndrome, or male XX hermaphroditism, the hypothesis of hydrocephalus was not taken into account. We don't have clear elements to hypothesize a certain etiology of Charles II' hydrocephalus; however, we think the herpetic infection he suffered of after his birth should not be ignored.
西班牙哈布斯堡王朝国王和西班牙海外帝国的君主查理二世身体残疾、面容畸形、智力迟钝，并且被证实没有生育能力。他在历史上被称为“被施了魔法的人”（El Hechizado），因为他和人民都相信他的身心缺陷是由于“巫术行为”。尽管有几位作者推测了不同的疾病，其中大多数是遗传性的，如垂体激素缺乏、远端肾小管酸中毒、克莱恩费尔特综合征、脆性 X 综合征或男性 XX 两性畸形，但脑积水的假说并未被考虑在内。我们没有明确的元素来假设查理二世脑积水的特定病因；然而，我们认为他出生后所患的疱疹感染不应该被忽视。
