Jain Akriti G, Sharbatji Mohamad, Afzal Ali, Afridi Summia Matin, Gordon Dwayne
Internal Medicine, Florida Hospital, Orlando, USA.
Cureus. 2019 Mar 9;11(3):e4213. doi: 10.7759/cureus.4213.
Pyoderma gangrenosum (PG) is a rare non-infectious skin disease of undetermined origin. It is characterized by a single or multiple painful, necrotic ulcers. Formerly, PG was assumed to be infectious, but eventually, it was established to be an inflammatory disorder that is commonly associated with autoimmune and neoplastic diseases. We report a case of PG in a 70-year-old female who presented on the pretibial area as a single non-healing ulcer. It started as a small induration that worsened over the course of two weeks despite being on antibiotics. We started the patient on corticosteroids and high potency topical steroids that resulted in healing of the ulcer. PG can prove to be a diagnostic dilemma and can be inappropriately treated with antibiotics or even something radical like an amputation if misdiagnosed. Hence, physicians need to think of this entity even in the absence of any predisposing conditions.
坏疽性脓皮病（PG）是一种病因不明的罕见非感染性皮肤病。其特征为单个或多个疼痛性坏死性溃疡。以前，PG被认为具有传染性，但最终确定它是一种炎症性疾病，通常与自身免疫性疾病和肿瘤性疾病相关。我们报告一例70岁女性的PG病例，该病例表现为胫前区单个不愈合溃疡。起初为一个小硬结，尽管使用了抗生素，但在两周内病情仍恶化。我们让患者开始使用皮质类固醇和高效外用类固醇，溃疡得以愈合。PG可能会成为诊断难题，如果误诊，可能会不恰当地使用抗生素治疗，甚至进行像截肢这样激进的治疗。因此，即使在没有任何易感因素的情况下，医生也需要考虑到这种疾病。
