Eshraghi Hamoon, Sanvicente Carina T, Gogte Priyanka, Waisbourd Michael, Lee Daniel, Manzi Remy R S, Leiby Benjamin E, Richman Jesse, Wizov Sheryl S, Spaeth George L
Rutgers Robert Wood Johnson Medical School; New Brunswick , NJ , United States.
Glaucoma Research Center, Wills Eye Hospital , Philadelphia , PA , USA.
Ophthalmic Epidemiol. 2019 Oct;26(5):301-310. doi: 10.1080/09286586.2019.1616773. Epub 2019 May 22.
: To investigate: 1) the impact of reduced contrast sensitivity (CS) in specific areas of vision on subjective assessment of vision-related quality of life (VRQoL) and objective performance-based measures in patients with primary open-angle, primary angle-closure, and pseudoexfoliation glaucoma; and 2) correlations between measurements of contrast sensitivity (CS) in specific areas of vision and visual field (VF) tests. : The Spaeth/Richman Contrast Sensitivity Test (SPARCS) measured CS in the inferior, superior, and central areas, while the Pelli-Robson test measured central CS. Visual fields were tested in participants using standard-automated perimetry. The National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) assessed VRQoL, and the Compressed Assessment of Ability Related to Vision (CAARV) assessed vision-related performance. : Three hundred and twenty-two eyes of 161 participants were included in our analysis. Significant correlations were found between CS and VF scores in the inferior, central, and superior areas ( < .0001 for all). Significant correlations were found between SPARCS scores in the inferior areas in both eyes and most CAARV scores ( < .05). Significant correlations were also found between SPARCS scores in the inferior and superior areas in the worse eye and most NEI-VFQ -25 scores ( < .05). : Contrast sensitivity and VF scores significantly correlated in all tested areas. Reduced CS in the inferior areas of both eyes affected most performance-based measures. Measurement of CS areas using SPARCS is a meaningful way to assess VRQoL and ability to perform daily activities in participants with glaucoma.
1）研究原发性开角型青光眼、原发性闭角型青光眼和假性剥脱性青光眼患者特定视野区域对比敏感度（CS）降低对视力相关生活质量（VRQoL）主观评估及基于客观表现的指标的影响；2）研究特定视野区域对比敏感度（CS）测量值与视野（VF）测试之间的相关性。方法：使用斯佩斯/里奇曼对比敏感度测试（SPARCS）测量下方、上方和中央区域的CS，同时使用佩利-罗布森测试测量中央CS。采用标准自动视野计对参与者进行视野测试。使用美国国立眼科研究所视觉功能问卷（NEI-VFQ-25）评估VRQoL，使用视力相关能力综合评估（CAARV）评估视力相关表现。结果：161名参与者的322只眼睛纳入我们的分析。发现下方、中央和上方区域的CS与VF评分之间存在显著相关性（均P<0.0001）。发现双眼下方区域的SPARCS评分与大多数CAARV评分之间存在显著相关性（P<0.05）。还发现较差眼下方和上方区域的SPARCS评分与大多数NEI-VFQ-25评分之间存在显著相关性（P<0.05）。结论：所有测试区域的对比敏感度与VF评分均显著相关。双眼下方区域CS降低影响了大多数基于表现的指标。使用SPARCS测量CS区域是评估青光眼患者VRQoL和日常活动能力的一种有意义的方法。
