CO/光氧化还原双催化α-溴代酮和胺的串联氧化环化反应构建取代恶唑。
CO/Photoredox-Cocatalyzed Tandem Oxidative Cyclization of α-Bromo Ketones and Amines To Construct Substituted Oxazoles.
机构信息
School of Chemistry and Environment , Yunnan Minzu University , Kunming , Yunnan 650500 , China.
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming , Yunnan 650500 , China.
出版信息
J Org Chem. 2019 Jun 21;84(12):8225-8231. doi: 10.1021/acs.joc.9b00283. Epub 2019 May 31.
PMID:31117554
Abstract
CO/photoredox-cocatalyzed tandem oxidative cyclization of α-bromo ketones and amines for the preparation of substituted oxazoles has been achieved. The avoidance of using both transition-metal catalysts and peroxides makes this method more sustainable and renewable.
摘要
实现了 CO/光氧化还原共催化的α-溴代酮和胺的串联氧化环化反应，用于制备取代恶唑。这种方法避免了使用过渡金属催化剂和过氧化物，因此更加可持续和可再生。
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