Yamada T, Isemura M, Yamaguchi Y, Munakata H, Hayashi N, Kyogoku M
Histochemistry. 1987;86(6):579-84. doi: 10.1007/BF00489550.
The distribution of fibronectin in the human placenta was studied by the aid of the immunoperoxidase technique using specific antibodies against it. In the early chorionic tissue, fibronectin was distributed along the trophoblastic basement membrane, on the wall of fetal blood vessels, in the connective tissue core, and in the cytotrophoblastic cell columns. In the term placenta, this glycoprotein was detected mainly on the fetal blood vessels and less intensely in the stroma, but not along the trophoblastic basement membrane. Endothelial cells of the blood vessels, fibroblastic cells in the stroma, and unidentified cells in the cytotrophoblastic cell columns were immunostained positively for fibronectin. These data suggest that fibronectin of the placenta is produced locally and retained in the tissue, if not all.
借助免疫过氧化物酶技术，使用针对纤连蛋白的特异性抗体，研究了其在人胎盘中的分布。在早期绒毛组织中，纤连蛋白沿滋养层基底膜、胎儿血管壁、结缔组织核心以及细胞滋养层细胞柱分布。在足月胎盘中，这种糖蛋白主要在胎儿血管上被检测到，在基质中的染色强度较低，但不在滋养层基底膜上。血管内皮细胞、基质中的成纤维细胞以及细胞滋养层细胞柱中的未鉴定细胞对纤连蛋白呈阳性免疫染色。这些数据表明，胎盘纤连蛋白是局部产生并保留在组织中的，即便不是全部。
