Department of Radiology, Van Lokman Hekim Private Hospital, Van, Turkey
Department of Radiology, Faculty of Medicine, Gazi University, Ankara, Turkey
Turk J Med Sci. 2019 Jun 18;49(3):844-853. doi: 10.3906/sag-1811-166.
BACKGROUND/AIM: Evaluating the relationship of patellar chondromalacia with obesity, infrapatellar fat pad (IFP) volume and popliteal artery intima-media thickness (IMT).
A total of203 patients with different degree of patellar chondromalacia (103 male, 100 female) and 52 control subjects (19 male, 33 female) were included and grouped according to sex, age, body surface area (BSA), body mass index (BMI) and patellar chondromalacia classification. All measurements were completed with 3T magnetic resonance imaging (MRI). Articular cartilage and IFP volume were measured in saggital plane using double echo steady state (DESS) and DIXON sequences, respectively. Patellar cartilage damage was graded using modified outerbridge classification, and the relations among cartilage volume and BMI, BSA, IFP, IMT were statistically assessed.
Popliteal artery IMT showed an independent association with the prevalence of cartilage defects and IFP volumes (P ˂ 0.001). There was an association between BMI and IFP volumes (P ˂ 0.001). However, no differences were observed between IFP volume and different chondromalacia groups. When IFP measurements were corrected using individual BMI and BSA values, a positive correlation was found between control and advanced chondromalacia groups (P ˂ 0.001).
This study demonstrates the relationship among obesity, IMT and chondromalacia and highlights this potential circle to develop effective treatments and inhibit the progression of chondromalacia.
背景/目的：评估髌股软骨软化症与肥胖、髌下脂肪垫（IFP）体积和腘动脉内膜中层厚度（IMT）的关系。
共纳入 203 例不同程度髌股软骨软化症患者（男 103 例，女 100 例）和 52 例对照组（男 19 例，女 33 例），根据性别、年龄、体表面积（BSA）、体重指数（BMI）和髌股软骨软化症分类进行分组。所有测量均采用 3T 磁共振成像（MRI）完成。关节软骨和 IFP 体积分别采用双回波稳态（DESS）和 DIXON 序列在矢状面测量。髌股软骨损伤采用改良 outerbridge 分级进行分级，并对软骨体积与 BMI、BSA、IFP、IMT 的关系进行统计学评估。
腘动脉 IMT 与软骨缺损和 IFP 体积的发生率呈独立相关（P ˂ 0.001）。BMI 与 IFP 体积之间存在相关性（P ˂ 0.001）。然而，IFP 体积与不同软骨软化症组之间没有差异。当使用个体 BMI 和 BSA 值校正 IFP 测量值时，对照组和高级软骨软化症组之间存在正相关（P ˂ 0.001）。
本研究表明肥胖、IMT 和软骨软化症之间存在关系，并强调了这一潜在循环，以开发有效的治疗方法并抑制软骨软化症的进展。
