Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.
Division of Pediatric General Medicine, Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan.
Pediatr Rheumatol Online J. 2021 May 12;19(1):71. doi: 10.1186/s12969-021-00554-w.
Among school-age children, the decrease of cartilage thickness (Cth) with increasing age is well known. However, the influence of body mass index (BMI), height or weight on Cth has not been revealed. Here in, we aim to establish an age- and gender-specific Cth standard reference among Asians and investigate the possible prestige of BMI, height and weight.
A cross-sectional study was performed in healthy Asian children. Bilateral knees, ankles, wrists, second metacarpophalangeals (MCPs) and proximal interphalangeals (PIPs) were measured using ultrasound. The children's height, weight and BMI were also recorded for later adjustment.
A total of 200 school age Asian children (including 86 girls and 114 boys, aged between 5 to 13 years-old) were investigated. Cth differences were observed in the knees, ankles, wrists, MCPs and PIPs between sexes (p < 0.05), with girls having thinner cartilage thickness. While Cth decreases with increasing age (p < 0.0001, 0.039, 0.001, 0.023, 0.091 in girls' knees, ankles, wrists, MCPs and PIPs and p = 0.002, 0.001, < 0.0001, 0.001, 0.045 in boys', respectively). Our data showed that weight, height and BMI are not the main factors contributing to Cth. A formula to calculate gender-specific cartilage thickness for Asian school age children is suggested. There was no difference in Cth after adjusting for height or weight between Asian or Caucasian group.
A formula to calculate gender-specific cartilage thickness for Asian school age children is suggested. Height, weight and BMI were not the major contributor for Cth among school age children.
在学龄儿童中，随着年龄的增长，软骨厚度（Cth）逐渐变薄是众所周知的。然而，体重指数（BMI）、身高或体重对 Cth 的影响尚未揭示。在此，我们旨在建立亚洲人群中年龄和性别特异性 Cth 标准参考，并探讨 BMI、身高和体重的可能影响。
本研究采用横断面研究方法，对健康的亚洲儿童进行双侧膝关节、踝关节、腕关节、第二掌指关节（MCPs）和近端指间关节（PIPs）的超声测量。同时记录儿童的身高、体重和 BMI，以便进行后续调整。
共纳入 200 名学龄期亚洲儿童（包括 86 名女孩和 114 名男孩，年龄 5 至 13 岁）。研究发现，膝关节、踝关节、腕关节、MCPs 和 PIPs 处的 Cth 在性别之间存在差异（p<0.05），女孩的软骨厚度较薄。随着年龄的增长，Cth 逐渐减少（p<0.0001、0.039、0.001、0.023、0.091 分别为女孩的膝关节、踝关节、腕关节、MCPs 和 PIPs，p=0.002、0.001、<0.0001、0.001、0.045 分别为男孩的膝关节、踝关节、腕关节、MCPs 和 PIPs）。我们的数据表明，体重、身高和 BMI 不是 Cth 的主要影响因素。我们建议了一个适用于亚洲学龄儿童的性别特异性软骨厚度计算公式。在调整身高或体重后，亚洲和高加索人群的 Cth 没有差异。
我们建议了一个适用于亚洲学龄儿童的性别特异性软骨厚度计算公式。身高、体重和 BMI 不是学龄儿童 Cth 的主要影响因素。
