有精神病性体验者的心理干预措施：系统评价和荟萃分析研究方案。
Psychological interventions for people with psychotic experiences: protocol for a systematic review and meta-analysis.
机构信息
Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK.
Department of Public Health and Primary Care, Cambridge Institute of Public Health, University of Cambridge, Cambridge, CB2 0SR, UK.
出版信息
Syst Rev. 2019 May 23;8(1):124. doi: 10.1186/s13643-019-1041-5.
BACKGROUND
Many people who have common mental disorders, such as depression and anxiety, also have some psychotic experiences. These experiences are associated with higher clinical complexity, poor treatment response, and negative clinical outcomes. Psychological interventions have the potential to improve outcomes for people with psychotic experiences. The aims of this systematic review are to (1) synthesise the evidence on the effectiveness and cost-effectiveness of psychological interventions to reduce psychotic experiences and their associated distress and (2) identify key components of effective interventions.
METHODS
Our search strategy will combine terms for (1) psychological interventions, (2) psychotic experiences, and (3) symptoms associated with psychotic experiences. We will search the following online databases: MEDLINE, Embase, PsycINFO, all Cochrane databases, British Nursing Index (BNI), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Health Management Information Consortium (HMIC), Education Resources Information Center (ERIC), and EconLit. Our primary outcome is the proportion of people who recovered or remitted from psychotic experiences after the intervention. Our secondary outcomes are changes in positive psychotic symptoms, negative psychotic symptoms, depression, anxiety, functioning (including social, occupational, and academic), quality of life, and cost-effectiveness. Two independent reviewers will judge each study against pre-specified inclusion and exclusion criteria and will extract study characteristics, outcome data, and intervention components. Risk of bias and methodological quality will be assessed using the Effective Public Health Practice Project Quality Assessment Tool for Quantitative Studies and the Drummond Checklist. Results will be synthesised using random-effects meta-analysis and narrative synthesis.
DISCUSSION
The identification of effective psychological interventions and of specific components associated with intervention effectiveness will augment existing evidence that can inform the development of a new, tailored intervention to improve outcomes related to psychotic symptoms, anxiety and depression, distress, functioning, and quality of life.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42016033869.
背景
许多患有常见精神障碍（如抑郁症和焦虑症）的人也会出现一些精神病性体验。这些体验与更高的临床复杂性、治疗反应不良和负面临床结局相关。心理干预有可能改善精神病性体验患者的结局。本系统综述的目的是：(1) 综合评估心理干预减少精神病性体验及其相关痛苦的有效性和成本效益；(2) 确定有效干预的关键组成部分。
方法
我们的检索策略将结合以下术语：(1) 心理干预，(2) 精神病性体验，(3) 与精神病性体验相关的症状。我们将检索以下在线数据库：MEDLINE、Embase、PsycINFO、所有 Cochrane 数据库、英国护理索引（BNI）、护理学和相关健康文献累积索引（CINAHL）、健康管理信息联合会（HMIC）、教育资源信息中心（ERIC）和经济学文献索引（EconLit）。我们的主要结局是干预后精神病性体验缓解或痊愈的人数比例。我们的次要结局是阳性精神病症状、阴性精神病症状、抑郁、焦虑、功能（包括社会、职业和学业）、生活质量和成本效益的变化。两名独立的审查员将根据预先设定的纳入和排除标准对每项研究进行判断，并提取研究特征、结局数据和干预组成部分。使用有效公共卫生实践项目质量评估工具（针对定量研究）和 Drummond 清单评估偏倚风险和方法学质量。结果将使用随机效应荟萃分析和叙述性综合进行综合。
讨论
识别有效的心理干预措施和与干预效果相关的特定组成部分，将增加现有的证据，为制定新的、量身定制的干预措施提供信息，以改善与精神病症状、焦虑和抑郁、痛苦、功能和生活质量相关的结局。
系统综述注册
PROSPERO CRD42016033869。
Zotero 插件