Campbell C, Tadros N, Heimbecker R O
J Heart Transplant. 1986 Nov-Dec;5(6):465-70.
A new method of heterotopic heart-lung transplantation in the rabbit neck is described. Fourteen animals have received transplants with a view to studying the simultaneous histologic changes of early rejection. Seven animals have been treated with cyclosporine; a similar group of seven animals received no immunosuppressive therapy. Cardiac rejection has been characterized by a diffuse infiltrate of mononuclear cells progressing to myocyte necrosis and eventually to global infarction. In the lung the changes of rejection have been reflected especially on the vascular bed, with proliferative endothelial changes involving small- and medium-sized arteries often to the point of occlusion. There has been a striking lack of correlation between the severity of the lesions in the two organs. Prevention of graft rejection by cyclosporine has not been possible because of the susceptibility of rabbits to Pasteurella pneumonia. This new model also holds promise for the evaluation of graft function in acute situations.
本文描述了一种在兔颈部进行异位心肺移植的新方法。为了研究早期排斥反应的同时组织学变化，14只动物接受了移植。7只动物接受了环孢素治疗；另一组7只动物未接受免疫抑制治疗。心脏排斥反应的特征是单核细胞弥漫性浸润，进而发展为心肌细胞坏死，最终导致全心梗死。在肺中，排斥反应的变化尤其体现在血管床，增殖性内皮变化累及中小动脉，常导致血管闭塞。两个器官病变的严重程度之间明显缺乏相关性。由于兔子对巴氏杆菌肺炎易感，因此无法通过环孢素预防移植物排斥反应。这种新模型也有望用于评估急性情况下的移植物功能。
