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干燥综合征：低剂量纳曲酮治疗的临床益处。

Sjogren's Syndrome: Clinical Benefits of Low-dose Naltrexone Therapy.

作者信息

Zashin Scott

机构信息

Rheumatology, University of Texas Southwest Medical Center, Dallas, USA.

出版信息

Cureus. 2019 Mar 11;11(3):e4225. doi: 10.7759/cureus.4225.

DOI:10.7759/cureus.4225
PMID:31123647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6510571/
Abstract

Sjogren's Syndrome is a chronic autoimmune disorder that causes the inflammation of the lacrimal and salivary glands, resulting in dryness of the eyes and mouth. In addition, fatigue and musculoskeletal pain, often described as aching, is very common. Treatment directed toward alleviating the fatigue and pain associated with Sjogren's is currently very limited. This report describes a case of a 47-year-old female with suspected Sjogren's based on long-standing dry eyes, dry mouth, joint pain, fatigue, elevated measures of inflammation, and a positive rheumatoid factor. She failed standard therapy but improved clinically with low-dose naltrexone therapy.

摘要

干燥综合征是一种慢性自身免疫性疾病，会导致泪腺和唾液腺发炎，从而引起眼睛和口腔干燥。此外，疲劳和肌肉骨骼疼痛（通常表现为酸痛）也非常常见。目前，针对缓解干燥综合征相关疲劳和疼痛的治疗方法非常有限。本报告描述了一名47岁女性的病例，该患者因长期存在干眼、口干、关节疼痛、疲劳、炎症指标升高以及类风湿因子呈阳性而疑似患有干燥综合征。她的标准治疗无效，但低剂量纳曲酮治疗使其临床症状有所改善。