Kumar P P, Good R R, Plantz S H, Hynes P R
J Natl Med Assoc. 1987 Jun;79(6):609-15.
Improper postoperative pelvic radiation of 5,000 rad in five weeks results in poor patient tolerance, unacceptable complications, and increased local recurrence. Preoperative or postoperative low-dose pelvic radiation results in better tolerance; however, in patients with resectable adenocarcinoma of the rectum and rectosigmoid, low-dose radiation improves neither the local failure rate nor the survival rate compared with treatment by surgery alone. The authors' technique was to deliver 5,000 rad in six weeks only to the pelvic tissues at risk for recurrence following surgery.
术后五周内给予5000拉德的不当盆腔放疗会导致患者耐受性差、出现不可接受的并发症以及局部复发增加。术前或术后低剂量盆腔放疗耐受性更好;然而,对于可切除的直肠和直肠乙状结肠腺癌患者,与单纯手术治疗相比,低剂量放疗既不能提高局部失败率,也不能提高生存率。作者的技术是在六周内仅对术后有复发风险的盆腔组织给予5000拉德的放疗。