Joó F
Neuropathol Appl Neurobiol. 1987 May-Jun;13(3):161-76. doi: 10.1111/j.1365-2990.1987.tb00181.x.
The molecular mechanisms operating within the cerebral endothelium have been analysed in relation to the formation of brain oedema states. With respect to their pathogenesis, the activation of a cyclic nucleotide-generating system and lipolysis seems in particular to be of neuropathological importance. As these molecular mechanisms were seen to be activated in oedemas with primary vascular reactions and in those following ischaemic brain injury, it is proposed that, from a pathogenetic point of view, brain oedemas have a common vascular origin.
已针对脑水肿状态的形成对脑内皮细胞内起作用的分子机制进行了分析。就其发病机制而言，环核苷酸生成系统的激活和脂肪分解似乎尤其具有神经病理学重要性。由于这些分子机制在原发性血管反应性水肿以及缺血性脑损伤后的水肿中均被发现处于激活状态，因此从发病机制的角度来看，有人提出脑水肿具有共同的血管起源。
