Joó F
Laboratory of Molecular Neurobiology, Institute of Biophysics, Szeged, Hungary.
Adv Exp Med Biol. 1993;331:155-64. doi: 10.1007/978-1-4615-2920-0_25.
The view that the cerebral endothelial cells represent the cellular analogue of the blood brain barrier has been generally accepted. The regulation of transport processes operating in the cerebral endothelial cells is of great current interest. Different elements of the intracellular signaling messenger systems have been detected in the course of our studies in the cerebral endothelial cells. Our knowledge of these regulatory mechanisms is briefly reviewed here with special emphasis on the importance of second messenger molecules and phosphorylation of certain proteins of microvascular origin.
大脑内皮细胞代表血脑屏障的细胞类似物这一观点已被普遍接受。目前，人们对大脑内皮细胞中运行的转运过程的调节非常感兴趣。在我们对大脑内皮细胞的研究过程中，已检测到细胞内信号信使系统的不同成分。在此简要回顾我们对这些调节机制的认识，特别强调第二信使分子的重要性以及微血管来源的某些蛋白质的磷酸化。
