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急性心肌梗死:存活率是否取决于地理位置和社会背景?

Acute myocardial infarction: Does survival depend on geographical location and social background?

机构信息

National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.

Department of Population Health, Auckland University, New Zealand.

出版信息

Eur J Prev Cardiol. 2019 Nov;26(17):1828-1839. doi: 10.1177/2047487319852680. Epub 2019 May 24.

Abstract

AIMS

This study described the interplay between geographical and social inequalities in survival after incident acute myocardial infarction (AMI) and examined whether geographical variation in survival exists when accounting for sociodemographic characteristics of the patients and their neighbourhood.

METHODS

Ringmap visualization and generalized linear models were performed to study post-AMI mortality. Three individual-level analyses were conducted: immediate case fatality, mortality between days 1 and 28 after admission and 365-day survival among patients who survived 28 days after admission.

RESULTS

In total, 99,013 incident AMI cases were registered between 2005 and 2014 in Denmark. Survival after AMI tended to correlate with sociodemographic indicators at the municipality level. In individual-level models, geographical inequality in immediate case fatality was observed with high mortality in northern parts of Jutland after accounting for sociodemographic characteristics. In contrast, no geographical variation in survival was observed among patients who survived 28 days. In all three analyses, odds and rates of mortality were higher among patients with low educational level (odds ratio (OR) (95% credible intervals) of 1.20 (1.12-1.29), OR of 1.12 (1.01-1.24) and mortality rate ratio of 1.45 (1.30-1.61)) and low income (OR of 1.24 (1.15-1.33), OR of 1.33 (1.20-1.48) and mortality rate ratio of 1.25 (1.13-1.38)).

CONCLUSION

Marked geographical inequality was observed in immediate case fatality. However, no geographically unequal distribution of survival was found among patients who survived 28 days after AMI. Results additionally showed social inequality in survival following AMI.

摘要

目的

本研究描述了在发生急性心肌梗死(AMI)后,生存方面的地理和社会不平等之间的相互作用,并检验了当考虑到患者及其所在社区的社会人口特征时,生存方面是否存在地理差异。

方法

采用环形图可视化和广义线性模型来研究 AMI 后的死亡率。进行了三项个体水平分析:即时病死率、住院后 1-28 天的死亡率和住院后存活 28 天的患者的 365 天生存率。

结果

在丹麦,2005 年至 2014 年间共登记了 99013 例急性 AMI 病例。AMI 后的生存情况与市一级的社会人口指标呈正相关。在个体水平模型中,在考虑了社会人口特征后,发现日德兰半岛北部地区即时病死率存在地理不平等现象,死亡率较高。相反,在存活 28 天的患者中,未观察到生存方面的地理差异。在所有三项分析中,教育程度较低的患者(比值比(OR)(95%可信区间)为 1.20(1.12-1.29),OR 为 1.12(1.01-1.24),死亡率比为 1.45(1.30-1.61))和收入较低的患者(OR 为 1.24(1.15-1.33),OR 为 1.33(1.20-1.48),死亡率比为 1.25(1.13-1.38))的死亡风险和死亡率均较高。

结论

即时病死率存在明显的地理不平等现象。然而,在 AMI 后存活 28 天的患者中,未发现生存方面的地理分布不均。研究结果还表明,AMI 后生存方面存在社会不平等现象。

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