Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 106, Taiwan, ROC.
Department of Chemical Engineering, National Taiwan University, Taiwan.
Anal Chim Acta. 2019 Sep 13;1071:98-108. doi: 10.1016/j.aca.2019.04.058. Epub 2019 May 6.
In this work, we report a sensitive and selective electrochemical sensor for the detection of dopamine (DA) neurotransmitter based on VS-SnS/f-MWCNT hybrids. Herein, the binary metal sulfide (VS-SnS) was synthesized via single step hydrothermal route and hybrids with f-MWCNT via the ultrasonication process. The as-prepared VS-SnS/f-MWCNT hybrids were characterized through the FESEM, EDX and elemental mapping, TEM, XPS, Raman and XRD techniques. The electrochemical performance and catalytic activity of the modified electrodes were probed using electrochemical impedance spectra (EIS), cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Interestingly, DPV results exhibits an appreciable linear range from 0.025 to 1017 μM and LOD of 0.008 μM. The selectivity study was performed to prove the high selectivity of the VS-SnS/f-MWCNT hybrids modified electrode. Furthermore, the practical applicability of the DA sensor was scrutinized in human serum sample and rat brain sample.
在这项工作中，我们基于 VS-SnS/f-MWCNT 杂化材料报道了一种用于检测多巴胺 (DA) 神经递质的灵敏、选择性电化学传感器。在此，通过单步水热法合成了二元金属硫化物 (VS-SnS)，并通过超声处理将其与 f-MWCNT 制成杂化材料。通过 FESEM、EDX 和元素映射、TEM、XPS、拉曼和 XRD 技术对所制备的 VS-SnS/f-MWCNT 杂化材料进行了表征。通过电化学阻抗谱 (EIS)、循环伏安法 (CV) 和差分脉冲伏安法 (DPV) 研究了修饰电极的电化学性能和催化活性。有趣的是，DPV 结果显示出从 0.025 到 1017 μM 的可观线性范围和 0.008 μM 的检测限。进行了选择性研究以证明 VS-SnS/f-MWCNT 杂化材料修饰电极具有高选择性。此外，还在人血清样品和大鼠脑组织样品中仔细研究了 DA 传感器的实际适用性。
