Institute for Experimental Cellular Therapy, University Hospital, Essen, Germany; Anthony Nolan Research Institute, Royal Free Hospital, London, UK; Centro de Investigaciones en Hematología y Trastornos Afines (CIHATA), Universidad de Costa Rica, San José, Costa Rica.
Escuela de Medicina, Universidad de Costa Rica, San José, Costa Rica.
Hum Immunol. 2019 Jul;80(7):413-414. doi: 10.1016/j.humimm.2019.05.006. Epub 2019 May 23.
A total of 221 Costa Rican Mestizos from the Central Valley were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, -DRB1, and -DQB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A24:02:01-B40:02:01-C03:05-DRB108:02:01-DQB1*04:02:01, with an estimated frequency of 2.04%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Costa Rica Central Valley Mestizo" and the identifier AFN3606.
采用基于序列的分型方法，对来自哥斯达黎加中部山谷的 221 名梅斯蒂索人进行了人类白细胞抗原（HLA）A、B、C、DRB1 和 DQB1 基因座的高分辨率基因分型。计算了相应的等位基因和扩展单体型频率以及哈迪-温伯格比例。确定的最常见的扩展单体型为 A24:02:01-B40:02:01-C03:05-DRB108:02:01-DQB1*04:02:01，估计频率为 2.04%。在所研究的任何基因座均未发现偏离哈迪-温伯格平衡。本报告的人群样本的 HLA 基因型数据可在等位基因频率网络数据库中公开获得，人群名称为“哥斯达黎加中部山谷梅斯蒂索人”，标识符为 AFN3606。
