Institute for Experimental Cellular Therapy, University Hospital, Essen, Germany; Anthony Nolan Research Institute, Royal Free Hospital, London, UK; Centro de Investigaciones en Hematología y Trastornos Afines (CIHATA), Universidad de Costa Rica, San José, Costa Rica.
Escuela de Medicina, Universidad de Costa Rica, San José, Costa Rica.
Hum Immunol. 2019 Jul;80(7):409-410. doi: 10.1016/j.humimm.2019.05.008. Epub 2019 May 22.
A total of 125 Costa Ricans of Amerindian descent were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A24:02:01-B40:02:01-C03:05-DRB104:07:01G, with an estimated frequency of 8.26%. A deviation from Hardy-Weinberg Equilibrium was detected at the DRB1 locus (p = 0.099). The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Costa Rica Amerindians" and the identifier AFN3608.
共对 125 名哥斯达黎加美洲印第安人进行了高分辨率人类白细胞抗原（HLA）基因座 HLA-A、-B、-C 和-DRB1 的基因分型，采用基于序列的分型方法。计算了相应的等位基因和扩展单体型频率以及哈迪-温伯格比例。确定的最常见的扩展单体型为 A24:02:01-B40:02:01-C03:05-DRB104:07:01G，估计频率为 8.26%。在 DRB1 基因座检测到与哈迪-温伯格平衡的偏离（p=0.099）。此处报告的人群样本的 HLA 基因型数据可在等位基因频率网络数据库中以人群名称“Costa Rica Amerindians”和标识符 AFN3608 公开获得。
