Brorson J E, Larsson P
Scand J Infect Dis. 1987;19(2):243-6. doi: 10.3109/00365548709032406.
The antibacterial activity of erythromycin to 50 beta-hemolytic streptococci group A was assessed using disc diffusion and MIC techniques on solid media at pHs 6, 7 and 8 in CO2, aerobic and anaerobic atmospheres. The majority of the strains were only intermediately sensitive to erythromycin according to the disc diffusion method, whereas they were sensitive as judged by the MIC determination. This demonstrates that the regression line is invalid for the drug-bug combination of erythromycin and beta-hemolytic streptococci group A. It was also shown that the activity of erythromycin is reduced at a lower pH and in CO2 incubation.
在pH值为6、7和8的条件下，于二氧化碳、需氧和厌氧环境的固体培养基上，采用纸片扩散法和最低抑菌浓度（MIC）技术评估了红霉素对50株A组β溶血性链球菌的抗菌活性。根据纸片扩散法，大多数菌株对红霉素仅为中度敏感，而通过MIC测定判断它们是敏感的。这表明红霉素与A组β溶血性链球菌的药物-细菌组合的回归线是无效的。还表明，在较低pH值和二氧化碳培养条件下，红霉素的活性会降低。
