Liashenko Iu I, Khodyrev A P
Antibiotiki. 1978 Jun;23(6):549-52.
Susceptibility of 64 beta-hemolytic streptococcal strains isolated from the patients with sore throat was studied by the method of serial dilutions in fluid nutrient medium (Konikov broth). Heterogenecity with respect to the sensitivity was investigated in 34 strains among separate populations of the microbes (10 to 15 in every strain). The MIC of benzylpenicillin, oxacillin and erythromycin ranged within 0.007--0.24 U/ml, 0.02--0.36 gamma/ml and 0.005--0.1 gamma/ml respectively. The MIC of benzylpenicillin with respect to separate populations most sensitive to it was 0.007--0.015 U/ml, while that with respect to the lease sensitive populations ranged from 0.015 to 0.24 U/ml. The respective values for oxacillin were 0.02--0.12 and 0.18--0.36 gamma/ml and those for erythromycin were 0.005--0.025 and 0.05--0.1 gamma/ml. Therefore, the beta-hemolytic streptococci isolated from the patients with sore throat were characterized by a rather high sensitivity to the antibiotics which was important precondition for their efficiency in treatment of the patients with the above disease.
采用在液体营养培养基（科尼科夫肉汤）中连续稀释的方法，对从咽喉痛患者中分离出的64株β溶血性链球菌菌株的敏感性进行了研究。在微生物的不同群体（每个菌株10至15个）中的34株菌株中研究了敏感性的异质性。苄青霉素、苯唑西林和红霉素的最低抑菌浓度分别在0.007--0.24 U/ml、0.02--0.36γ/ml和0.005--0.1γ/ml范围内。苄青霉素对最敏感的不同群体的最低抑菌浓度为0.007--0.015 U/ml，而对最不敏感群体的最低抑菌浓度范围为0.015至0.24 U/ml。苯唑西林的相应值为0.02--0.12和0.18--0.36γ/ml，红霉素的相应值为0.005--0.025和0.05--0.1γ/ml。因此，从咽喉痛患者中分离出的β溶血性链球菌对这些抗生素具有相当高的敏感性，这是它们对上述疾病患者治疗有效的重要前提。
