Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention Prevention Research Centers, Atlanta, Georgia, USA.
ICF International Inc, Fairfax, Virginia, USA.
BMJ Open. 2019 May 24;9(5):e024212. doi: 10.1136/bmjopen-2018-024212.
The research literature addressing pre-exposure prophylaxis (PrEP) has increased considerably over the last decade. To better understand the research areas and explore research gaps, we will conduct a scoping review to map study topics and describe study characteristics and populations in publications focused on PrEP. The purpose of this protocol is to describe planned methods for the scoping review.
We will implement a comprehensive systematic literature search to identify PrEP citations in the United States Centres for Disease Control and Prevention HIV/AIDS Prevention Research Synthesis Project database that is unique and extensively focuses on HIV/sexually transmitted infections/hepatitis. We will screen and include studies that are (1) focused on HIV PrEP, (2) primary research with human participants and (3) published in English. Two reviewers will independently abstract data on authors' names, study years, countries, population characteristics and design. To describe and summarise study topics, we will use 19 codes and five categories that were developed from a preliminary study. The five categories are (behaviours/issues for potential PrEP takers/healthcare professionals), (experiences of and problems related to staying on or prescribing PrEP), (biomedical aspects and medication efficacy), (possesses/experiences of clinical trials) and (cost studies). Data will be analysed with descriptive statistics.
The findings will be presented at HIV-related conferences and published in peer-review journals.
过去十年中，针对暴露前预防（PrEP）的研究文献大量增加。为了更好地了解研究领域并探索研究空白，我们将进行范围综述，以绘制研究主题图，并描述专注于 PrEP 的出版物中的研究特征和人群。本方案旨在描述计划的范围综述方法。
我们将实施全面的系统文献检索，以确定美国疾病预防控制中心艾滋病毒/艾滋病预防研究综合项目数据库中独特且广泛关注艾滋病毒/性传播感染/肝炎的 PrEP 引用。我们将筛选并纳入以下研究：（1）专注于 HIV PrEP，（2）针对人类参与者的主要研究，以及（3）以英文发表。两名评审员将独立提取作者姓名、研究年份、国家、人口特征和设计的数据。为了描述和总结研究主题，我们将使用从初步研究中开发的 19 个代码和五个类别。五个类别是（潜在 PrEP 使用者/医疗保健专业人员的行为/问题）、（与坚持或开处 PrEP 相关的经验和问题）、（生物医学方面和药物疗效）、（临床试验的经验/经历）和（成本研究）。将使用描述性统计数据对数据进行分析。
研究结果将在与艾滋病毒相关的会议上进行介绍，并发表在同行评议的期刊上。
