Newcomb Michael E, Mongrella Melissa C, Weis Benjamin, McMillen Samuel J, Mustanski Brian
Department of Medical Social Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL.
J Acquir Immune Defic Syndr. 2016 Feb 1;71(2):200-6. doi: 10.1097/QAI.0000000000000819.
Recent advances in biomedical prevention strategies, including pre-exposure prophylaxis (PrEP) and achieving an undetectable viral load (UVL) among HIV-infected persons, show promise in curbing the rising incidence of HIV among men who have sex with men (MSM) in the United States. This mixed-methods study aimed to investigate the frequency with which MSM encounter potential sex partners on geosocial networking apps who disclose biomedical prevention use, and how MSM make decisions about condom use after these disclosures.
Participants were recruited through advertisements placed on a large geosocial networking app for MSM. A total of 668 and 727 participants, respectively, responded to questionnaires assessing partner disclosure of PrEP use and UVL. Each questionnaire included an open-ended item assessing reasons for condomless anal sex (CAS) with partners using biomedical prevention.
Across both surveys, most respondents encountered potential sex partners who disclosed PrEP use or UVL, and the majority of those who met up with these partners engaged in CAS at least once. Qualitative analyses found that most participants who reported CAS did so after making a calculated risk about HIV transmission. We also describe a novel risk reduction strategy, "biomed-matching," or having CAS only when both individuals use PrEP or have UVL. We report serostatus differences in both quantitative and qualitative findings.
Disclosure of PrEP use and UVL is not uncommon among MSM. Many MSM make accurate appraisals of the risks of CAS with biomedical prevention, and mobile apps may aid with disclosing biomedical prevention use.
生物医学预防策略取得了新进展,包括暴露前预防(PrEP)以及让艾滋病毒感染者的病毒载量达到检测不到的水平(UVL),这些进展有望抑制美国男男性行为者(MSM)中不断上升的艾滋病毒发病率。这项混合方法研究旨在调查男男性行为者在地理社交网络应用程序上遇到披露生物医学预防措施使用情况的潜在性伴侣的频率,以及男男性行为者在这些披露之后如何做出使用避孕套的决定。
通过在一款面向男男性行为者的大型地理社交网络应用程序上投放广告招募参与者。共有668名和727名参与者分别回复了评估伴侣PrEP使用情况和UVL披露情况的问卷。每份问卷都包含一个开放式问题,评估与使用生物医学预防措施的伴侣进行无保护肛交(CAS)的原因。
在两项调查中,大多数受访者都遇到过披露PrEP使用情况或UVL的潜在性伴侣,并且与这些伴侣见面的大多数人至少有过一次无保护肛交。定性分析发现,大多数报告有无保护肛交的参与者是在对艾滋病毒传播进行风险计算之后才这样做的。我们还描述了一种新的风险降低策略,即“生物医学匹配”,也就是只有当双方都使用PrEP或都处于病毒载量检测不到的水平时才进行无保护肛交。我们在定量和定性研究结果中均报告了血清学状态差异。
在男男性行为者中,披露PrEP使用情况和UVL并不罕见。许多男男性行为者能够准确评估使用生物医学预防措施时无保护肛交的风险,并且移动应用程序可能有助于披露生物医学预防措施的使用情况。