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脉冲式甲泼尼龙治疗青少年特发性关节炎后出现严重急性高眼压症。

Severe acute ocular hypertension following pulsed methylprednisolone for juvenile idiopathic arthritis.

作者信息

Beverstock Andrew, Kelly Alison

机构信息

Department of Paediatric Orthopaedics, Bristol Royal Hospital for Children, Bristol, UK.

Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK.

出版信息

BMJ Case Rep. 2019 May 24;12(5):e229803. doi: 10.1136/bcr-2019-229803.

DOI:10.1136/bcr-2019-229803
PMID:31129643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6536218/
Abstract

We report the case of a 6-year-old girl with juvenile idiopathic arthritis and anterior uveitis who was treated with two doses of intravenous methylprednisolone for acute arthritis. She developed severe ocular hypertension (intraocular pressures (IOPs) of 54 mm Hg in the right eye and 61 mm Hg in the left eye) requiring inpatient therapy with intravenous acetazolamide. The normal range of values for IOP is 12-22 mm Hg. This severe case of acute intraocular hypertension due to systemic steroids highlights the need to consider monitoring of IOPs for children on high-dose topical and systemic steroids with risk factors for raised IOP.

摘要

我们报告了一例6岁患有幼年特发性关节炎和前葡萄膜炎的女孩,她因急性关节炎接受了两剂静脉注射甲泼尼龙治疗。她出现了严重的高眼压(右眼眼压54毫米汞柱,左眼眼压61毫米汞柱),需要住院接受静脉注射乙酰唑胺治疗。眼压的正常范围值为12 - 22毫米汞柱。这例因全身使用类固醇导致的严重急性高眼压病例凸显了对于有眼压升高风险因素且正在接受高剂量局部和全身类固醇治疗的儿童,需要考虑监测眼压。

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本文引用的文献

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Steroid-induced protracted severe ocular hypertension in a 14-year-old girl.一名14岁女孩出现类固醇诱导的持续性严重高眼压症。
BMJ Case Rep. 2018 Jun 27;2018:bcr-2018-225244. doi: 10.1136/bcr-2018-225244.
2
Steroid-induced Glaucoma: An Avoidable Irreversible Blindness.类固醇性青光眼:一种可避免的不可逆性失明。
J Curr Glaucoma Pract. 2017 May-Aug;11(2):67-72. doi: 10.5005/jp-journals-l0028-1226. Epub 2017 Aug 5.
3
Under pressure: an ocular complication of oral corticosteroid therapy.压力之下:口服皮质类固醇治疗的眼部并发症
BMJ Case Rep. 2012 Sep 11;2012:bcr2012006955. doi: 10.1136/bcr-2012-006955.
4
The effect of intravitreal triamcinolone on intraocular pressure.玻璃体内注射曲安奈德对眼压的影响。
Curr Med Res Opin. 2007 Jun;23(6):1253-8. doi: 10.1185/030079907X187946. Epub 2007 Apr 25.
5
Intraocular pressure elevation after intravitreal triamcinolone acetonide injection.玻璃体内注射曲安奈德后眼压升高
Ophthalmology. 2005 Apr;112(4):593-8. doi: 10.1016/j.ophtha.2004.10.042.