铜催化通过 C-N 键断裂的炔丙胺与硫的串联硫化/环化反应。
Copper-Catalyzed Tandem Sulfuration/Annulation of Propargylamines with Sulfur via C-N Bond Cleavage.
机构信息
College of Chemistry and Materials Engineering , Wenzhou University , Wenzhou 325035 , China.
Guangxi Key Laboratory of Calcium Carbonate Resources Comprehensive Utilization , Hezhou University , Hezhou 542899 , China.
出版信息
J Org Chem. 2019 Jun 21;84(12):7894-7900. doi: 10.1021/acs.joc.9b00685. Epub 2019 Jun 7.
PMID:31132264
Abstract
Copper-catalyzed aerobic oxidative sulfuration and annulation of propargylamines with elemental sulfur is described. The tandem reaction involves C-N bond cleavage and the formation of multiple C-S bonds, affording 1,2-dithiole-3-thiones in good to excellent yields with good functional group tolerance.
摘要
本文报道了铜催化的炔丙胺与单质硫的有氧氧化硫化和环化反应。该串联反应涉及 C-N 键的断裂和多个 C-S 键的形成，以良好到优异的收率得到了 1,2-二硫杂环戊-3-硫酮，具有良好的官能团耐受性。
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