N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect, 119991 Moscow, Russia.
Nanotechnology Education and Research Center, South Ural State University, 454080 Chelyabinsk, Russia.
Molecules. 2021 Jun 11;26(12):3595. doi: 10.3390/molecules26123595.
3-1,2-Dithiole-3-thiones are among the best studied classes of polysulfur-containing heterocycles due to the almost explosive recent interest in these compounds as sources of hydrogen sulfide as an endogenously produced gaseous signaling molecule. This review covers the recent developments in the synthesis of these heterocycles, including both well-known procedures and important novel transformations for building the 1,2-dithiole-3-thione ring. Diverse ring transformations of 3-1,2-dithiole-3-thiones into various heterocyclic systems through 1,3-dipolar cycloaddition, replacement of one or two sulfur atoms to form carbon- and carbon-nitrogen containing moieties, and other unexpected reactions are considered.
3-1,2-二硫杂环戊烯-3-硫酮类化合物是含多硫杂环的化合物中研究最多的一类，这主要是因为最近人们对这些化合物作为内源性产生的气体信号分子硫化氢的来源产生了浓厚的兴趣。本文综述了这些杂环的最新合成进展，包括构建 1,2-二硫杂环戊烯-3-硫酮环的知名方法和重要的新型转化。通过 1,3-偶极环加成，3-1,2-二硫杂环戊烯-3-硫酮可以转化为各种杂环系统，通过取代一个或两个硫原子形成含碳和含碳-氮的部分，以及其他意想不到的反应也进行了考虑。
