Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China.
Org Biomol Chem. 2020 May 6;18(17):3234-3238. doi: 10.1039/d0ob00074d.
Herein, iodide-catalyzed aerobic synthesis of 1,4-benzothiazines via functionalization of multiple C-H bonds with elemental sulfur is described. Beyond the well-established thiazole formation from elemental sulfur, this method provides the first access to the corresponding six-membered N,S-heterocyclic products via direct functionalization of multiple C-H bonds. Hence, 1,4-benzothiazine products were generated in satisfactory yields with a range of compatible functionalities.
本文描述了通过元素硫的多 C-H 键官能化实现碘催化的 1,4-苯并噻嗪的有氧合成。除了通过元素硫形成已确立的噻唑之外，该方法还通过多 C-H 键的直接官能化提供了获得相应的六元 N，S-杂环产物的首例。因此，以一系列相容的官能团，以令人满意的产率生成了 1,4-苯并噻嗪产物。
