Sato N, Kawano S, Fukuda M, Tsuji S, Kamada T
Am J Med. 1987 Jul 27;83(1A):15-21. doi: 10.1016/0002-9343(87)90573-0.
The effects of misoprostol on human gastric mucosal hemodynamics were examined in a double-blind, placebo-controlled, parallel study in 12 healthy male volunteers. Six subjects received 200 micrograms of misoprostol and six received placebo. The index of mucosal blood volume and mucosal blood hemoglobin oxygen saturation (Hb-SO2) were measured at 20 locations in the stomach using reflectance spectrophotometry during endoscopy prior to and after administration of the study drug. Mucosal blood volume index increased by approximately 10 to 25 percent throughout the stomach without a significant change in mucosal Hb-SO2 following treatment with misoprostol. The increase in mucosal blood volume index was statistically significant for 16 of the 20 locations (p less than or equal to 0.05). Placebo produced no significant change in mucosal blood volume and mucosal Hb-SO2. These findings suggest that misoprostol may have the potential effect of accelerating gastric ulcer healing by improving gastric mucosal hemodynamics, in addition to its gastric acid antisecretory activity.
在一项针对12名健康男性志愿者的双盲、安慰剂对照、平行研究中，检测了米索前列醇对人胃黏膜血流动力学的影响。6名受试者接受200微克米索前列醇，6名接受安慰剂。在给予研究药物之前和之后，在内镜检查期间，使用反射分光光度法在胃内20个位置测量黏膜血容量指数和黏膜血红蛋白氧饱和度（Hb-SO2）。用米索前列醇治疗后，整个胃黏膜血容量指数增加了约10%至25%，而黏膜Hb-SO2没有显著变化。20个位置中的16个位置黏膜血容量指数的增加具有统计学意义（p≤0.05）。安慰剂对黏膜血容量和黏膜Hb-SO2没有显著影响。这些发现表明，米索前列醇除了具有胃酸分泌抑制活性外，还可能具有通过改善胃黏膜血流动力学来加速胃溃疡愈合的潜在作用。
