Eleftheriadis E, Kotzampassi K, Tzartinoglou E, Salem A, Aletras H
Department of Surgery, University of Thessaloniki, Greece.
Gastroenterol Jpn. 1991 Jun;26(3):283-6. doi: 10.1007/BF02781915.
The belief that blood flow plays a central role in cytoprotection and there being no data available, at present, regarding the possible action of Colloidal bismuth subcitrate (CBS-DENOL) on the gastric mucosal blood flow (GMBF), led us to investigate its influence on mucosal hemodynamics in the rat stomach. Measurements of GMBF were performed in 32 male Wistar rats, treated by either CBS or placebo in drinking water for a 3-wk period, by the use of a laser-Doppler flowmeter, at 14 defined points of the stomach. CBS treated animals revealed a highly statistically significant increase (P less than 0.0005, upaired t-test) of GMBF in comparison with the placebo treated. These findings lead us to suggest that CBS exerts its antiulcer action via the mechanism of increased gastric mucosal blood flow. Additionally the increased blood flow may be associated with the previous findings of increased synthesis of prostaglandins, gastric mucus and bicarbonate secretion by CBS.
认为血流在细胞保护中起核心作用，且目前尚无关于枸橼酸铋钾（CBS - DENOL）对胃黏膜血流（GMBF）可能作用的数据，这促使我们研究其对大鼠胃黏膜血流动力学的影响。在32只雄性Wistar大鼠中进行GMBF测量，这些大鼠在饮水中分别接受CBS或安慰剂处理3周，使用激光多普勒血流仪在胃的14个特定点进行测量。与接受安慰剂处理的动物相比，接受CBS处理的动物显示GMBF有高度统计学显著增加（P小于0.0005，未配对t检验）。这些发现使我们认为CBS通过增加胃黏膜血流的机制发挥其抗溃疡作用。此外，血流增加可能与先前关于CBS增加前列腺素合成、胃黏液和碳酸氢盐分泌的发现有关。
