The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.
Curr Opin Immunol. 2019 Jun;58:68-74. doi: 10.1016/j.coi.2019.04.007. Epub 2019 May 24.
The differentiation of B cells into antibody-secreting plasma cells is associated with profound changes in morphology, lifespan, and cellular metabolism that are needed to support high rates of antibody production. These processes are driven by dramatic alterations to the transcriptional program and to the organization of the nucleus itself that in turn are regulated by the activity of a select group of transcription factors and epigenetic regulators. Although the core differentiation program is conserved in all mature B cells, subset-specific regulators, such as those found in B1 or memory B cells, provide additional complexity. Here, we review the key components of the gene regulatory network controlling B-cell terminal differentiation, with an emphasis on the new players and processes that have emerged in recent years.
B 细胞分化为分泌抗体的浆细胞伴随着形态、寿命和细胞代谢的深刻变化，这些变化是支持高抗体产生率所必需的。这些过程是由转录程序的显著改变以及核本身的组织引起的，而这些改变反过来又受到一组特定的转录因子和表观遗传调节剂的调节。尽管所有成熟 B 细胞中都存在核心分化程序，但亚群特异性调节剂，如在 B1 或记忆 B 细胞中发现的那些，提供了额外的复杂性。在这里，我们综述了控制 B 细胞终末分化的基因调控网络的关键组成部分，重点介绍了近年来出现的新参与者和新过程。
