IHMA Europe Sàrl, Monthey, Switzerland.
Servicio de Microbiología, Hospital Universitario Ramón y Cajal & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
Future Microbiol. 2019 Jun;14:773-787. doi: 10.2217/fmb-2019-0089. Epub 2019 May 28.
To explore the antibacterial spectrum of ozenoxacin and compare its activity with that of other antibacterial agents. In 2010, 10,054 isolates were collected from 128 centers worldwide. Minimum inhibitory concentrations against Gram-positive and Gram-negative isolates were determined for 23 and 13 antibacterial agents, respectively. Ozenoxacin exhibited high activity against susceptible, and methicillin- or levofloxacin-resistant, Gram-positive bacteria. Ozenoxacin was one or two dilutions less active against Enterobacteriaceae isolates, except for , than other quinolones. Ozenoxacin is a potent antimicrobial agent mainly against susceptible and resistant strains of Gram-positive isolates (staphylococci and streptococci), and shows activity against some Gram-negative isolates.
为了探索奥扎诺星的抗菌谱，并比较其活性与其他抗菌药物的活性。2010 年，从全球 128 个中心收集了 10054 株分离株。分别对 23 种和 13 种抗菌药物的革兰阳性和革兰阴性分离株的最小抑菌浓度进行了测定。奥扎诺星对敏感、耐甲氧西林或左氧氟沙星的革兰阳性菌具有很高的活性。奥扎诺星对肠杆菌科分离株的活性比其他喹诺酮类药物低一至两个稀释度，除 外。奥扎诺星是一种主要针对革兰阳性菌（葡萄球菌和链球菌）敏感和耐药株的强效抗菌药物，对一些革兰阴性菌也有活性。
