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用于治疗脓疱病的局部抗生素疗法的理想特性:一份意大利专家共识报告。

Ideal Features of Topical Antibiotic Therapy for the Treatment of Impetigo: An Italian Expert Consensus Report.

作者信息

Neri Iria, Miraglia Del Giudice Michele, Novelli Andrea, Ruggiero Giuseppe, Pappagallo Giovanni, Galli Luisa

机构信息

Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.

Department of Woman and Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples, Italy.

出版信息

Curr Ther Res Clin Exp. 2022 Dec 24;98:100690. doi: 10.1016/j.curtheres.2022.100690. eCollection 2023.

DOI:10.1016/j.curtheres.2022.100690
PMID:36712177
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9881045/
Abstract

BACKGROUND

A group of Italian experts in impetigo medical care sought to define 10 statements to describe the ideal characteristics of the best local antibiotic treatments, and to provide relevant information re- garding their appropriate use and prescription that should be considered in clinical practice for impetigo management.

OBJECTIVE

A group of Italian experts in impetigo medical care sought to define 10 statements to describe the ideal characteristics of the best local antibiotic treatments, and to provide relevant information regarding their appropriate use and prescription that should be considered in clinical practice for impetigo management.

METHODS

A consensus on ideal features of antibiotic therapy for the treatment of impetigo was appraised by an online Delphi-based method, based on a panel of 61 infectious disease specialists, pediatricians, and dermatologists coordinated by a scientific committee of 5 experts specializing in impetigo management.

RESULTS

Full or very high consensus was reached on the 10 statements identified to describe the characteristics of the best hypothetic antibiotic therapy for impetigo together with indications for appropriate antibiotics use.

CONCLUSIONS

Several criteria have to be considered when selecting topical antibacterial therapy for impetigo. Beyond efficacy and safety, antimicrobial susceptibility and pharmacological characteristics of the agent are essential points. Formulation of the antimicrobial product is fundamental, as well as patient and caregiver preference, to facilitate therapeutic adherence, to achieve the infection control, and to obtain the best benefit from treatment ( 2023; 84:XXXXXX).

摘要

背景

一组意大利脓疱病医疗专家试图确定10条陈述,以描述最佳局部抗生素治疗的理想特征,并提供有关其在脓疱病管理临床实践中应考虑的适当使用和处方的相关信息。

目的

一组意大利脓疱病医疗专家试图确定10条陈述,以描述最佳局部抗生素治疗的理想特征,并提供有关其在脓疱病管理临床实践中应考虑的适当使用和处方的相关信息。

方法

基于由5名专门从事脓疱病管理的专家组成的科学委员会协调的61名传染病专家、儿科医生和皮肤科医生小组,通过基于德尔菲法的在线方法评估了脓疱病治疗中抗生素治疗理想特征的共识。

结果

就确定的10条陈述达成了完全或非常高的共识,这些陈述描述了脓疱病最佳假设抗生素治疗的特征以及适当使用抗生素的指征。

结论

在为脓疱病选择局部抗菌治疗时必须考虑几个标准。除了疗效和安全性外,药物的抗菌敏感性和药理学特征是关键点。抗菌产品的配方至关重要,患者和护理人员的偏好也很重要,以促进治疗依从性、实现感染控制并从治疗中获得最大益处(2023;84:XXXXXX)。

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本文引用的文献

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Pediatric impetigo: an expert panel opinion about its main controversies.小儿脓疱疮:专家小组对其主要争议的意见。
J Chemother. 2022 Sep;34(5):279-285. doi: 10.1080/1120009X.2021.1961185. Epub 2021 Aug 18.
2
In vitro activity and resistance rates of topical antimicrobials fusidic acid, mupirocin and ozenoxacin against skin and soft tissue infection pathogens obtained across Canada (CANWARD 2007-18).在加拿大各地(CANWARD 2007-18)获得的皮肤和软组织感染病原体的体外活性和局部抗菌药物(夫西地酸、莫匹罗星和奥洛昔康)的耐药率。
J Antimicrob Chemother. 2021 Jun 18;76(7):1808-1814. doi: 10.1093/jac/dkab098.
3
A comparative review of current topical antibiotics for impetigo.当前治疗脓疱疮的局部用抗生素的比较评价。
Expert Opin Drug Saf. 2021 Jun;20(6):677-683. doi: 10.1080/14740338.2021.1902502. Epub 2021 Apr 13.
4
Association between fluoroquinolone resistance and MRSA genotype in Alexandria, Egypt.埃及亚历山大市氟喹诺酮耐药与 MRSA 基因型的相关性。
Sci Rep. 2021 Feb 19;11(1):4253. doi: 10.1038/s41598-021-83578-2.
5
Do Antimicrobial Resistance Patterns Matter? An Algorithm for the Treatment of Patients With Impetigo.抗微生物药物耐药模式是否重要?治疗脓疱疮患者的算法。
J Drugs Dermatol. 2021 Feb 1;20(2):134-142. doi: 10.36849/JDD.5745.
6
The Use of Ozenoxacin in Pediatric Patients: Clinical Evidence, Efficacy and Safety.奥泽沙星在儿科患者中的应用:临床证据、疗效与安全性
Front Pharmacol. 2020 Nov 18;11:559708. doi: 10.3389/fphar.2020.559708. eCollection 2020.
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Intolerable Burden of Impetigo in Endemic Settings: A Review of the Current State of Play and Future Directions for Alternative Treatments.地方病流行地区脓疱疮的难以承受之重:当前状况综述及替代治疗的未来方向
Antibiotics (Basel). 2020 Dec 15;9(12):909. doi: 10.3390/antibiotics9120909.
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Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails.当天然抗菌防御失效时治疗皮肤感染的抗生素递送策略。
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Topical antimicrobial therapy: Current status and challenges.局部抗菌治疗:现状与挑战。
Indian J Med Microbiol. 2019 Jul-Sep;37(3):299-308. doi: 10.4103/ijmm.IJMM_19_443.
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