Rotolo Ornella, Zinzi Iris, Veronese Nicola, Cisternino Anna M, Reddavide Rosa, Inguaggiato Rosa, Leandro Gioacchino, Notarnicola Maria, Tutino Valeria, De Nunzio Valentina, De Leonardis Giampiero, Guerra Vito, Donghia Rossella, Fucilli Fabio, Licinio Raffaella, Mastrosimini Anna, Rinaldi Caterina C M, Daddabbo Tiziana, Giampaolo Nicola, Iacovazzi Palma A, Giannico Sara, Caruso Maria G
Ambulatory of Clinical Nutrition, National Institute of Gastroenterology, Research Hospital, IRCCS "Saverio de Bellis" of Castellana Grotte (BA), Italy.
Unit of Gastrenterology 1, National Institute of Gastroenterology, Research Hospital, IRCCS "Saverio de Bellis" of Castellana Grotte (BA), Italy.
Endocr Metab Immune Disord Drug Targets. 2019;19(8):1232-1239. doi: 10.2174/1871530319666190528101532.
In the postmenopausal period, most women suffer vasomotor symptoms (VMS). It is well-known that VMS can worsen the quality of life. Diet seems to play a relevant role in the development of VMS, but the effect of diet on VMS is mainly limited to observational studies, and analyses of nutritional supplements. The aim of this study was thus to determine the efficacy of a lactoovo- vegetarian (LOVe) diet rich in omega-3 fatty acids vs. a lacto-ovo-vegetarian diet rich in EVO (extra-virgin olive oil) in reducing VMS frequency in postmenopausal women.
A two-arms (lacto-ovo-vegetarian diet with EVO vs. lacto-ovo-vegetarian diet rich in omega-3) randomized-controlled trial with a follow-up period of 16 weeks. We considered as primary outcome the change in the Kupperman index (follow-up vs. baseline evaluation, reported as delta, D) and in its subscales. Secondary outcomes included changes in common anthropometric and biohumoral measurements.
Among 54 women randomly assigned to a study group, 40 (mean age 55.1±5.4 years) completed the study and complied with their assigned diet. Women randomized to the omega-3 group (n=18) showed significant improvements, compared to the EVO group (n=22), in Kupperman index (Δ=-11.4±9.8 vs. -5.9±8.2; p=0.045), hot flashes (Δ=-3.3±3.4 vs. -1.3±2.6; p=0.04), and a marginally significant improvement in nervousness (Δ=-1.7±1.7 vs. -0.8±1.5; p=0.07). No significant differences were observed for the secondary outcomes. No relevant side effects were reported.
After 16 weeks, a lacto-ovo-vegetarian diet rich in omega-3 reduced VMS frequency in postmenopausal women more than the lacto-ovo-vegetarian diet rich in EVO.
在绝经后期，大多数女性会出现血管舒缩症状（VMS）。众所周知，VMS会降低生活质量。饮食似乎在VMS的发生发展中起重要作用，但饮食对VMS的影响主要局限于观察性研究以及营养补充剂分析。因此，本研究的目的是确定富含ω-3脂肪酸的乳蛋素食（LOVe）饮食与富含特级初榨橄榄油（EVO）的乳蛋素食饮食在降低绝经后女性VMS频率方面的疗效。
一项双臂（富含EVO的乳蛋素食饮食与富含ω-3的乳蛋素食饮食）随机对照试验，随访期为16周。我们将库珀曼指数（随访与基线评估相比，以差值，即D表示）及其子量表的变化作为主要结局。次要结局包括常见人体测量和生物体液测量的变化。
在随机分配到研究组的54名女性中，40名（平均年龄55.1±5.4岁）完成了研究并遵守了分配的饮食。与EVO组（n = 22）相比，随机分配到ω-3组（n = 18）的女性在库珀曼指数（Δ=-11.4±9.8对-5.9±8.2；p = 0.045）、潮热（Δ=-3.3±3.4对-1.3±2.6；p = 0.04）方面有显著改善，在紧张方面有边缘性显著改善（Δ=-1.7±1.7对-0.8±1.5；p = 0.07）。次要结局未观察到显著差异。未报告相关副作用。
16周后，富含ω-3的乳蛋素食饮食比富含EVO的乳蛋素食饮食更能降低绝经后女性的VMS频率。
