Jiang Wei, Wu Dong-Bo, Xiao Gui-Bao, Ding Bei, Chen En-Qiang
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
Department of Infectious Diseases, The First People's Hospital of Ziyang, Ziyang 641300, China.
Med Clin (Barc). 2020 Jan 10;154(1):7-12. doi: 10.1016/j.medcli.2019.03.019. Epub 2019 May 24.
There is growing evidence that vitamin D is related to the development of a variety of diseases. The current study was performed to investigate the status of serum vitamin D distribution among adult Chinese people and reveal the influence of gender, age, seasonality and residential regions on serum vitamin D levels.
This cross-sectional study included 14,302 participants aged from 18 years old to 65 years old from six major cities in China. The basic demographic information and the levels of serum vitamin D (25(OH)D) and vitamin D (25(OH)D) were collected from Jan 2, 2014 to Dec 25, 2017.
The prevalence of 25(OH)D concentration <30ng/mL reached up to 83%, in which the rate of vitamin D insufficiency (20-29ng/mL) was 32.7%, and vitamin D deficiency (10-19ng/mL) accounted for 41.9%, and vitamin D severe shortage (<10ng/mL) accounted for 8.4%. Women were more likely to have vitamin D deficiency and lower serum vitamin D concentration than men (both p<0.001). The mean concentration of serum 25(OH)D and 25(OH)D in summer and autumn were higher than that in spring and winter (p<0.001), and the mean concentration of serum 25(OH)D in people from Southern China was higher than that in people from other regions (p<0.001). Although the mean concentrations of serum 25(OH)D and 25(OH)D were both increased by age, the percentage of patients with serum 25(OH)D insufficiency was also increased.
Serum vitamin D deficiency is very common in adults in China. The level of serum vitamin D may be associated with age, sex, seasonality and residential regions.
越来越多的证据表明维生素D与多种疾病的发生有关。本研究旨在调查中国成年人血清维生素D的分布状况，并揭示性别、年龄、季节和居住地区对血清维生素D水平的影响。
这项横断面研究纳入了来自中国六个主要城市的14302名年龄在18岁至65岁之间的参与者。收集了2014年1月2日至2017年12月25日期间的基本人口统计学信息以及血清维生素D（25(OH)D）水平。
25(OH)D浓度<30ng/mL的患病率高达83%，其中维生素D不足（20 - 29ng/mL）率为32.7%，维生素D缺乏（10 - 19ng/mL）占41.9%，维生素D严重缺乏（<10ng/mL）占8.4%。女性比男性更易患维生素D缺乏且血清维生素D浓度更低（均p<0.001）。夏季和秋季血清25(OH)D和25(OH)D的平均浓度高于春季和冬季（p<0.001），中国南方人群血清25(OH)D的平均浓度高于其他地区人群（p<0.001）。尽管血清25(OH)D和25(OH)D的平均浓度均随年龄增加而升高，但血清25(OH)D不足患者的百分比也增加。
血清维生素D缺乏在中国成年人中非常普遍。血清维生素D水平可能与年龄、性别、季节和居住地区有关。
